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Literature DB >> 19081748

Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium.

Anne Pfister¹, Guoqing Zhang, Jessica Zareno, Alan F Horwitz, Cassandra L Fraser.

Abstract

Difluoroboron dibenzoylmethane-polylactide, BF(2)dbmPLA, a biocompatible polymer-luminophore conjugate was fabricated as nanoparticles. Spherical particles <100 nm in size were generated via nanoprecipitation. Intense blue fluorescence, two-photon absorption, and long-lived room temperature phosphorescence (RTP) are retained in aqueous suspension. The nanoparticles were internalized by cells and visualized by fluorescence microscopy. Luminescent boron biomaterials show potential for imaging and sensing.

Entities: Chemical

Keywords: boron dye; fluorescence; nanoparticles; phosphorescence; poly(lactic acid) (PLA)

Mesh：

Substances：

Year: 2008 PMID： 19081748 PMCID： PMC2600552 DOI： 10.1021/nn7003525

Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881

34 in total

Review 1. Small-scale systems for in vivo drug delivery.

Authors: David A LaVan; Terry McGuire; Robert Langer
Journal: Nat Biotechnol Date: 2003-10 Impact factor: 54.908

2. Encapsulation of p-THPP into nanoparticles: cellular uptake, subcellular localization and effect of serum on photodynamic activity.

Authors: Y N Konan; J Chevallier; R Gurny; E Allémann
Journal: Photochem Photobiol Date: 2003-06 Impact factor: 3.421

Review 3. Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate.

Authors: Vladimir P Torchilin
Journal: Adv Drug Deliv Rev Date: 2005-01-02 Impact factor: 15.470

Review 4. Nanomedicine: developing smarter therapeutic and diagnostic modalities.

Authors: Omid C Farokhzad; Robert Langer
Journal: Adv Drug Deliv Rev Date: 2006-10-30 Impact factor: 15.470

5. BODIPY dyes and their derivatives: syntheses and spectroscopic properties.

Authors: Aurore Loudet; Kevin Burgess
Journal: Chem Rev Date: 2007-10-09 Impact factor: 60.622

6. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.

Authors: Jianjun Cheng; Benjamin A Teply; Ines Sherifi; Josephine Sung; Gaurav Luther; Frank X Gu; Etgar Levy-Nissenbaum; Aleksandar F Radovic-Moreno; Robert Langer; Omid C Farokhzad
Journal: Biomaterials Date: 2006-10-20 Impact factor: 12.479

7. Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.

Authors: David M Cochran; Dai Fukumura; Marek Ancukiewicz; Peter Carmeliet; Rakesh K Jain
Journal: Ann Biomed Eng Date: 2006-07-11 Impact factor: 3.934

8. Iron tris(dibenzoylmethane)-centered polylactide stars: multiple roles for the metal complex in lactide ring-opening polymerization.

Authors: Jessica L Gorczynski; Jianbin Chen; Cassandra L Fraser
Journal: J Am Chem Soc Date: 2005-11-02 Impact factor: 15.419

9. Diaroyl(methanato)boron difluoride compounds as medium-sensitive two-photon fluorescent probes.

Authors: Emmanuelle Cogné-Laage; Jean-François Allemand; Odile Ruel; Jean-Bernard Baudin; Vincent Croquette; Mireille Blanchard-Desce; Ludovic Jullien
Journal: Chemistry Date: 2004-03-19 Impact factor: 5.236

10. Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulisification as an alternative to ultrasonic and high-shear devices.

Authors: François Ganachaud; Joseph L Katz
Journal: Chemphyschem Date: 2005-02 Impact factor: 3.102

31 in total

Boron polylactide nanoparticles exhibiting fluorescence and phosphorescence in aqueous medium.

Review 1. Small-scale systems for in vivo drug delivery.

2. Encapsulation of p-THPP into nanoparticles: cellular uptake, subcellular localization and effect of serum on photodynamic activity.

Review 3. Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate.

Review 4. Nanomedicine: developing smarter therapeutic and diagnostic modalities.

5. BODIPY dyes and their derivatives: syntheses and spectroscopic properties.

6. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.

7. Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.

8. Iron tris(dibenzoylmethane)-centered polylactide stars: multiple roles for the metal complex in lactide ring-opening polymerization.

9. Diaroyl(methanato)boron difluoride compounds as medium-sensitive two-photon fluorescent probes.

10. Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulisification as an alternative to ultrasonic and high-shear devices.

1. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells.

2. Oxygen Sensing Difluoroboron β-Diketonate Polylactide Materials with Tunable Dynamic Ranges for Wound Imaging.

3. Luminescent Difluoroboron β-Diketonate PLA-PEG Nanoparticle.

4. Near-infrared phosphorescent polymeric nanomicelles: efficient optical probes for tumor imaging and detection.

5. Tailoring Oxygen Sensitivity with Halide Substitution in Difluoroboron Dibenzoylmethane Polylactide Materials.

6. Labelling primary immune cells using bright blue fluorescent nanoparticles.

7. Luminescent difluoroboron β-diketonate PEG-PLA oxygen nanosensors for tumor imaging.

8. Optical imaging of tumor hypoxia dynamics.

9. A dual-emissive-materials design concept enables tumour hypoxia imaging.

10. Luminescent donor-acceptor beta-diketones: modulation of emission by solvent polarity and group II metal binding.