| Literature DB >> 19081720 |
Ghotas Evindar1, Sylvie G Bernier, Malcolm J Kavarana, Elisabeth Doyle, Jeanine Lorusso, Michael S Kelley, Keith Halley, Amy Hutchings, Albion D Wright, Ashis K Saha, Gerhard Hannig, Barry A Morgan, William F Westlin.
Abstract
In the design of potent and selective sphingosine-1-phosphate receptor agonists, we were able to identify two series of molecules based on phenylamide and phenylimidazole analogs of FTY-720. Several designed molecules in these scaffolds have demonstrated selectivity for S1P receptor subtype 1 versus 3 and excellent in vivo activity in mouse. Two molecules PPI-4621 (4b) and PPI-4691 (10a), demonstrated dose responsive lymphopenia, when administered orally.Entities:
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Year: 2008 PMID： 19081720 DOI： 10.1016/j.bmcl.2008.11.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823