BACKGROUND: The purpose of this study was to examine the 3-year clinical outcome in patients enrolled in the Primary Stenting of Totally Occluded Native Coronary Arteries II study. METHODS:Patients with totally occluded coronary arteries randomized to eithersirolimus-eluting Cypher stents (SESs) (Cordis, a Johnson & Joshson Company, Miami Lakes, FL) (100 patients) or bare-metal BxVelocity stents (BMSs) (Cordis) (100 patients) were followed clinically for 3 years. RESULTS: Between 1 and 3 years, there were infrequent additional clinical events that were equally distributed between the SES and the BMS group. After 3 years, target lesion revascularization was 7% in the SES group versus 27% in the BMS group (P < .001); and target vessel revascularization was seen in 11% in the SES group versus 30% in the BMS group (P = .002). Major adverse cardiac events were noted in 10% of the SES group versus 34% in the BMS group (P < .001). There were no statistically significant differences in death, myocardial infarction, and stent thrombosis according to the Academic Research Consortium criteria between the 2 groups. CONCLUSIONS: Clinical outcome up to 3 years after implantation of SESs for total coronary occlusions continues to demonstrate a significant reduction in adverse clinical events compared with BMSs without the evidence for either disproportionate late restenosis or late stent thrombosis.
RCT Entities:
BACKGROUND: The purpose of this study was to examine the 3-year clinical outcome in patients enrolled in the Primary Stenting of Totally Occluded Native Coronary Arteries II study. METHODS:Patients with totally occluded coronary arteries randomized to either sirolimus-eluting Cypher stents (SESs) (Cordis, a Johnson & Joshson Company, Miami Lakes, FL) (100 patients) or bare-metal BxVelocity stents (BMSs) (Cordis) (100 patients) were followed clinically for 3 years. RESULTS: Between 1 and 3 years, there were infrequent additional clinical events that were equally distributed between the SES and the BMS group. After 3 years, target lesion revascularization was 7% in the SES group versus 27% in the BMS group (P < .001); and target vessel revascularization was seen in 11% in the SES group versus 30% in the BMS group (P = .002). Major adverse cardiac events were noted in 10% of the SES group versus 34% in the BMS group (P < .001). There were no statistically significant differences in death, myocardial infarction, and stent thrombosis according to the Academic Research Consortium criteria between the 2 groups. CONCLUSIONS: Clinical outcome up to 3 years after implantation of SESs for total coronary occlusions continues to demonstrate a significant reduction in adverse clinical events compared with BMSs without the evidence for either disproportionate late restenosis or late stent thrombosis.
Authors: Xavier Freixa; Vladimír Džavík; Sandra A Forman; James M Rankin; Christopher E Buller; Warren J Cantor; Witold Ruzyllo; Harmony R Reynolds; Gervasio A Lamas; Judith S Hochman Journal: Am Heart J Date: 2012-06 Impact factor: 4.749
Authors: Ahmad Syadi Mahmood Zuhdi; Florian Krackhardt; Matthias W Waliszewski; Muhammad Dzafir Ismail; Michael Boxberger; Wan Azman Wan Ahmad Journal: Cardiol Res Pract Date: 2018-03-01 Impact factor: 1.866
Authors: Koen Teeuwen; Tom Adriaenssens; Ben J L Van den Branden; José P S Henriques; Rene J Van der Schaaf; Jacques J Koolen; Paul H M J Vermeersch; Mike A R Bosschaert; Jan G P Tijssen; Maarten J Suttorp Journal: Trials Date: 2012-12-15 Impact factor: 2.279