| Literature DB >> 19081365 |
Burcin Ikiz1, Serge Przedborski.
Abstract
p25/Cdk5 dysregulation may contribute to neurodegeneration. In this issue of Neuron, Kim et al. show that cdk5 inactivates HDAC-1, leading to cell cycle deregulation and DNA damage accumulation. This study provides further insights into the function of p25/Cdk5 in neurons and points to HDAC-1 as a target for therapeutic interventions.Entities:
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Year: 2008 PMID： 19081365 DOI： 10.1016/j.neuron.2008.11.020
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173