| Literature DB >> 19081249 |
Sungsik Cho1, Sangtae Oh, Yumi Um, Ji-Hee Jung, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee.
Abstract
Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a-h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity.Entities:
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Year: 2008 PMID： 19081249 DOI： 10.1016/j.bmcl.2008.11.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823