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Literature DB >> 19079267

Crystal structure of TIPE2 provides insights into immune homeostasis.

Xu Zhang¹, Jiawei Wang, Chao Fan, Hubo Li, Honghong Sun, Shunyou Gong, Youhai H Chen, Yigong Shi.

Abstract

TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.

Entities: Gene

Mesh：

Substances：

Year: 2008 PMID： 19079267 DOI： 10.1038/nsmb.1522

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

14 in total

Review 1. The death domain superfamily in intracellular signaling of apoptosis and inflammation.

Authors: Hyun Ho Park; Yu-Chih Lo; Su-Chang Lin; Liwei Wang; Jin Kuk Yang; Hao Wu
Journal: Annu Rev Immunol Date: 2007 Impact factor: 28.527

2. Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles.

Authors: Li-Ying Lin; Chung-Lun Ching; Ko-Hsin Chin; Shan-Ho Chou; Nei-Li Chan
Journal: Proteins Date: 2006-11-15

Review 3. Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

Authors: L Van Parijs; A K Abbas
Journal: Science Date: 1998-04-10 Impact factor: 47.728

4. Identification of seven differentially displayed transcripts in human primary and matched metastatic head and neck squamous cell carcinoma cell lines: implications in metastasis and/or radiation response.

Authors: S Patel; F H Wang; T L Whiteside; U Kasid
Journal: Oral Oncol Date: 1997-05 Impact factor: 5.337

5. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein.

Authors: D Kumar; T L Whiteside; U Kasid
Journal: J Biol Chem Date: 2000-01-28 Impact factor: 5.157

6. Expression of SCC in ovarian granulosa cells and cultured cells, induced rapid structural changes in mitochondria.

Authors: T Yoshinaga-Hirabayashi; Y Yoneda
Journal: Ital J Anat Embryol Date: 2001

7. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.

Authors: Honghong Sun; Shunyou Gong; Ruaidhri J Carmody; Anja Hilliard; Li Li; Jing Sun; Li Kong; Lingyun Xu; Brendan Hilliard; Shimin Hu; Hao Shen; Xiaolu Yang; Youhai H Chen
Journal: Cell Date: 2008-05-02 Impact factor: 41.582

8. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells.

Authors: Deepak Kumar; Prafulla Gokhale; Constantinos Broustas; Debyani Chakravarty; Imran Ahmad; Usha Kasid
Journal: Oncogene Date: 2004-01-15 Impact factor: 9.867

9. Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation.

Authors: Ruaidhrí J Carmody; Brendan Hilliard; Kimberly Maguschak; Lewis A Chodosh; Youhai H Chen
Journal: J Neuroimmunol Date: 2002-12 Impact factor: 3.478

Crystal structure of TIPE2 provides insights into immune homeostasis.

Review 1. The death domain superfamily in intracellular signaling of apoptosis and inflammation.

2. Crystal structure of the conserved hypothetical cytosolic protein Xcc0516 from Xanthomonas campestris reveals a novel quaternary structure assembled by five four-helix bundles.

Review 3. Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

4. Identification of seven differentially displayed transcripts in human primary and matched metastatic head and neck squamous cell carcinoma cell lines: implications in metastasis and/or radiation response.

5. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein.

6. Expression of SCC in ovarian granulosa cells and cultured cells, induced rapid structural changes in mitochondria.

7. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.

8. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells.

9. Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation.

Review 10. Fas and Fas ligand: lpr and gld mutations.

1. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.

2. Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection.

Review 3. Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins.

Review 4. The significance and regulatory mechanisms of innate immune cells in the development of sepsis.

Review 5. Role of inflammation and its mediators in acute ischemic stroke.

6. Clinical Significance of TIPE2 Protein Upregulation in Non-Hodgkin's Lymphoma.

7. TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.

8. TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.

9. Upregulation of SCC-S2 in immune cells and tumor tissues of papillary thyroid carcinoma.

10. TIPE2 regulates tumor-associated macrophages in skin squamous cell carcinoma.