| Literature DB >> 19078982 |
Abstract
In this issue, Denton et al., describe a mouse model of postnatal deletion of the transforming growth factor (TGF)-beta receptor type II (TbetaRII) in skin fibroblasts. Using a tamoxifen-dependent inducible Cre-lox strategy, the authors demonstrate the pivotal role played by TGF-beta signaling in fibroblasts during wound healing. Healing of full-thickness wounds after fibroblast-specific deletion of TbetaRII in the skin was severely impaired and exhibited delayed re-epithelialization. This study emphasizes the importance of fibroblasts in mesenchymal-epithelial interaction in the skin during wound repair.Entities:
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Year: 2009 PMID： 19078982 DOI： 10.1038/jid.2008.385
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551