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Literature DB >> 1907665

The molecular evolution of ZFY-related genes in birds and mammals.

Abstract

We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx.

Entities: Gene Species

Mesh：

Year: 1991 PMID： 1907665 DOI： 10.1007/bf02102189

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

20 in total

5. Male-biased distribution of the human Y chromosomal genes SRY and ZFY in the lizard Calotes versicolor, which lacks sex chromosomes and temperature-dependent sex determination.

Authors: S Ganesh; J Mohanty; R Raman
Journal: Chromosome Res Date: 1997-09 Impact factor: 5.239

6. Interchromosomal gene conversion as a possible mechanism for explaining divergence patterns of ZFY-related genes.

Authors: H Hayashida; K Kuma; T Miyata
Journal: J Mol Evol Date: 1992-08 Impact factor: 2.395

6 in total

The molecular evolution of ZFY-related genes in birds and mammals.

1. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.

2. Genetic evidence that ZFY is not the testis-determining factor.

3. Mammalian sex determination: thumbs down for zinc finger?

4. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

5. An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide.

6. Mammalian ZFY sequences exist in reptiles regardless of sex-determining mechanism.

7. A novel avian W chromosome DNA repeat sequence in the lesser black-backed gull (Larus fuscus).

8. Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.

9. Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.

10. Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.

1. Patterns of Y and X chromosome DNA sequence divergence during the Felidae radiation.

2. Potential problems in estimating the male-to-female mutation rate ratio from DNA sequence data.

3. Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

4. Contrasting rates of nucleotide substitution in the X-linked and Y-linked zinc finger genes.

5. Male-biased distribution of the human Y chromosomal genes SRY and ZFY in the lizard Calotes versicolor, which lacks sex chromosomes and temperature-dependent sex determination.

6. Interchromosomal gene conversion as a possible mechanism for explaining divergence patterns of ZFY-related genes.