AIM: Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as non-classical cardiovascular risk factors in end-stage renal disease patients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with endothelial function (EF) in peritoneal dialysis (PD) patients. METHODS: Fifty-two non-diabetic PD patients without known atherosclerotic disease as well as 30 age- and sex-matched healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end-product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and EF as described by Celermejer et al. in all subjects. RESULTS: TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PD patients than in controls (P < 0.001). Flow-mediated dilatation (FMD)% and nitrate mediated dilatation (NMD)% in PD patients were lower than in the control group (7.7 +/- 4.0% vs 11.70 +/- 5.50%, P < 0.01 and 17.6 +/- 8.3% vs 26.4 +/- 4.6%, P < 0.01). Additionally, it was found that AOPP are independently correlated with FMD% and NMD% in PD patients (beta = -463, P < 0.01 and beta = -420, P < 0.05). CONCLUSION: This study shows that PD patients without known atherosclerotic disease can also be characterized by endothelial dysfunction and AOPP levels independently predict endothelial function level in PD patients.
AIM: Oxidative stress (OS) and asymmetric dimethylarginine (ADMA) are accepted as non-classical cardiovascular risk factors in end-stage renal diseasepatients. To clarify the role of these factors in the atherosclerotic process, we investigated if OS and ADMA are associated with endothelial function (EF) in peritoneal dialysis (PD) patients. METHODS: Fifty-two non-diabeticPDpatients without known atherosclerotic disease as well as 30 age- and sex-matched healthy individuals were included. We measured serum thiobarbituric acid-reactive substances (TBARS), malondialdehyde (MDA), advanced glycation end-product (AGE), pentosidine, advanced oxidation protein products (AOPP), ADMA and EF as described by Celermejer et al. in all subjects. RESULTS:TBARS, MDA, AOPP, AGE, pentosidine and ADMA levels were significantly higher in PDpatients than in controls (P < 0.001). Flow-mediated dilatation (FMD)% and nitrate mediated dilatation (NMD)% in PDpatients were lower than in the control group (7.7 +/- 4.0% vs 11.70 +/- 5.50%, P < 0.01 and 17.6 +/- 8.3% vs 26.4 +/- 4.6%, P < 0.01). Additionally, it was found that AOPP are independently correlated with FMD% and NMD% in PDpatients (beta = -463, P < 0.01 and beta = -420, P < 0.05). CONCLUSION: This study shows that PDpatients without known atherosclerotic disease can also be characterized by endothelial dysfunction and AOPP levels independently predict endothelial function level in PDpatients.
Authors: Hong Xu; Ivan Cabezas-Rodriguez; Abdul Rashid Qureshi; Olof Heimburger; Peter Barany; Sunna Snaedal; Björn Anderstam; Ann-Christin Bragfors Helin; Juan Jesus Carrero; Peter Stenvinkel; Bengt Lindholm Journal: Perit Dial Int Date: 2014-03-01 Impact factor: 1.756
Authors: A Khaira; S Mahajan; A Kumar; S Prakash; A Saraya; B Singh; M Bora; S C Tiwari; S K Agarwal; D Bhowmik Journal: Indian J Nephrol Date: 2011-10
Authors: Marielle A Schroijen; Olaf M Dekkers; Diana C Grootendorst; Marlies Noordzij; Johannes A Romijn; Raymond T Krediet; Elisabeth W Boeschoten; Friedo W Dekker Journal: BMC Nephrol Date: 2011-12-19 Impact factor: 2.388
Authors: Emma L Taylor; Kenneth R Armstrong; David Perrett; Andrew T Hattersley; Paul G Winyard Journal: Oxid Med Cell Longev Date: 2015-05-14 Impact factor: 6.543