Literature DB >> 19075824

Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses.

Addmore Shonhai1, Melissa Botha, Tjaart A P de Beer, Aileen Boshoff, Gregory L Blatch.   

Abstract

The spatial orientation of domains of the heat shock protein 70 from Plasmodium falciparum (PfHsp70) were mapped based on a three-dimensional model of the protein. Purified PfHsp70 displayed chaperone activity in vitro. Amino acid substitutions introduced in the chaperone's substrate binding cavity compromised the protein's chaperone function.

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Year:  2008        PMID： 19075824     DOI： 10.2174/092986608786071067

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  20 in total

1.  Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock.

Authors:  Melissa Botha; Annette N Chiang; Patrick G Needham; Linda L Stephens; Heinrich C Hoppe; Simone Külzer; Jude M Przyborski; Klaus Lingelbach; Peter Wipf; Jeffrey L Brodsky; Addmore Shonhai; Gregory L Blatch
Journal:  Cell Stress Chaperones       Date:  2010-12-30       Impact factor: 3.667

2.  Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70.

Authors:  Tawanda Zininga; Ofentse J Pooe; Pertunia B Makhado; Lebogang Ramatsui; Earl Prinsloo; Ikechukwu Achilonu; Heinrich Dirr; Addmore Shonhai
Journal:  Cell Stress Chaperones       Date:  2017-04-28       Impact factor: 3.667

3.  Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1.

Authors:  Nicolaas Salomane; Ofentse J Pooe; Mthokozisi B C Simelane
Journal:  Cell Stress Chaperones       Date:  2021-05-23       Impact factor: 3.667

4.  Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding.

Authors:  Stanley Makumire; Tendamudzimu Harmfree Dongola; Graham Chakafana; Lufuno Tshikonwane; Cecilia Tshikani Chauke; Tarushai Maharaj; Tawanda Zininga; Addmore Shonhai
Journal:  Int J Mol Sci       Date:  2021-02-23       Impact factor: 5.923

5.  DnaK protein alleviates toxicity induced by citrate-coated gold nanoparticles in Escherichia coli.

Authors:  Stanley Makumire; Neerish Revaprasadu; Addmore Shonhai
Journal:  PLoS One       Date:  2015-04-02       Impact factor: 3.240

Review 6.  Plasmodial HSP70s are functionally adapted to the malaria parasite life cycle.

Authors:  Jude M Przyborski; Mathias Diehl; Gregory L Blatch
Journal:  Front Mol Biosci       Date:  2015-06-26

7.  Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein.

Authors:  Tawanda Zininga; Ikechukwu Achilonu; Heinrich Hoppe; Earl Prinsloo; Heini W Dirr; Addmore Shonhai
Journal:  PLoS One       Date:  2015-06-17       Impact factor: 3.240

8.  Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion.

Authors:  Tawanda Zininga; Ikechukwu Achilonu; Heinrich Hoppe; Earl Prinsloo; Heini W Dirr; Addmore Shonhai
Journal:  Cell Stress Chaperones       Date:  2016-02-19       Impact factor: 3.667

9.  Plasmodium falciparum Hop (PfHop) Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.

Authors:  Tawanda Zininga; Stanely Makumire; Grace Wairimu Gitau; James M Njunge; Ofentse Jacob Pooe; Hanna Klimek; Robina Scheurr; Hartmann Raifer; Earl Prinsloo; Jude M Przyborski; Heinrich Hoppe; Addmore Shonhai
Journal:  PLoS One       Date:  2015-08-12       Impact factor: 3.240

10.  Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei.

Authors:  Adélle Burger; Michael H Ludewig; Aileen Boshoff
Journal:  J Parasitol Res       Date:  2014-02-24
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