Literature DB >> 19075819

Concerted action of metals and macromolecular crowding on the fibrillation of alpha-synuclein.

Larissa A Munishkina1, Anthony L Fink, Vladimir N Uversky.   

Abstract

Certain metals lead to increased risk of Parkinson's disease (PD) and the aggregation of alpha-synuclein is implicated in the PD pathology. Although alpha-synuclein fibrillation has been extensively studied in dilute solutions in vitro, the intracellular environment is highly crowded. We are showing here that certain metals cause a significant acceleration of alpha-synuclein fibrillation in the presence of high concentrations of various macromolecules mostly through decreasing the fibrillation lagtime. The faster fibrillation in crowded environments in the presence of heavy metals suggests a simple molecular basis for the observed elevated risk of PD due to exposure to metals.

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Year:  2008        PMID： 19075819      PMCID： PMC2677187          DOI： 10.2174/092986608786071102

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  50 in total

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Journal:  Neurotoxicology       Date:  1992       Impact factor: 4.294

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Authors:  B A Rybicki; C C Johnson; J Uman; J M Gorell
Journal:  Mov Disord       Date:  1993       Impact factor: 10.338

Review 9.  Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.

Authors:  Vladimir N Uversky
Journal:  J Neurochem       Date:  2007-07-10       Impact factor: 5.372

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Authors:  S B Zimmerman; S O Trach
Journal:  J Mol Biol       Date:  1991-12-05       Impact factor: 5.469
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  6 in total

Review 1.  Exploring the accessible conformations of N-terminal acetylated α-synuclein.

Authors:  Gina M Moriarty; Maria K Janowska; Lijuan Kang; Jean Baum
Journal:  FEBS Lett       Date:  2013-03-13       Impact factor: 4.124

Review 2.  Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.

Authors:  Vladimir N Uversky; David Eliezer
Journal:  Curr Protein Pept Sci       Date:  2009-10       Impact factor: 3.272

3.  Molecular and neurochemical mechanisms in PD pathogenesis.

Authors:  Irmgard Paris; Jorge Lozano; Carolina Perez-Pastene; Patricia Muñoz; Juan Segura-Aguilar
Journal:  Neurotox Res       Date:  2009-05-20       Impact factor: 3.911

Review 4.  What macromolecular crowding can do to a protein.

Authors:  Irina M Kuznetsova; Konstantin K Turoverov; Vladimir N Uversky
Journal:  Int J Mol Sci       Date:  2014-12-12       Impact factor: 5.923

5.  Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.

Authors:  Deepthi Yedlapudi; Gnanada S Joshi; Dan Luo; Sokol V Todi; Aloke K Dutta
Journal:  Sci Rep       Date:  2016-12-05       Impact factor: 4.379

Review 6.  Parkinson's Disease: The Mitochondria-Iron Link.

Authors:  Yorka Muñoz; Carlos M Carrasco; Joaquín D Campos; Pabla Aguirre; Marco T Núñez
Journal:  Parkinsons Dis       Date:  2016-05-17
  6 in total

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