Literature DB >> 19075813

Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH.

Pratap Karki1, Giri Raj Dahal, Song Yub Shin, Jung Sup Lee, Byungyun Cho, Il-Seon Park.   

Abstract

The activity of caspase-2 was examined under varying biochemical conditions with the synthetic and protein substrates, Bid and procaspase-7. The results indicate that it was largely influenced by pH which might be one reason behind the inconsistency for the cleavage of its established substrates during caspase-2-induced apoptosis.

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Year:  2008        PMID： 19075813     DOI： 10.2174/092986608786071193

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  5 in total

1.  Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.

Authors:  Magdalena Wejda; Francis Impens; Nozomi Takahashi; Petra Van Damme; Kris Gevaert; Peter Vandenabeele
Journal:  J Biol Chem       Date:  2012-07-23       Impact factor: 5.157

2.  Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate.

Authors:  Tanja Kitevska; Sarah J Roberts; Delara Pantaki-Eimany; Sarah E Boyd; Fiona L Scott; Christine J Hawkins
Journal:  Biosci Rep       Date:  2014-04-01       Impact factor: 3.840

Review 3.  The role of caspase-2 in stress-induced apoptosis.

Authors:  Lisa Bouchier-Hayes
Journal:  J Cell Mol Med       Date:  2010-02-16       Impact factor: 5.310

Review 4.  The Role of Caspase-2 in Regulating Cell Fate.

Authors:  Vasanthy Vigneswara; Zubair Ahmed
Journal:  Cells       Date:  2020-05-19       Impact factor: 6.600

5.  Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death.

Authors:  H Vakifahmetoglu-Norberg; E Norberg; A B Perdomo; M Olsson; F Ciccosanti; S Orrenius; G M Fimia; M Piacentini; B Zhivotovsky
Journal:  Cell Death Dis       Date:  2013-12-05       Impact factor: 8.469
  5 in total

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