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Literature DB >> 19075631

Applications of lentiviral vectors for shRNA delivery and transgenesis.

Abstract

Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.

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Year: 2008 PMID： 19075631 PMCID： PMC2774780 DOI： 10.2174/156652308786848067

Source DB: PubMed Journal: Curr Gene Ther ISSN： 1566-5232 Impact factor: 4.391

45 in total

1. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

Authors: R Zufferey; J E Donello; D Trono; T J Hope
Journal: J Virol Date: 1999-04 Impact factor: 5.103

2. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.

Authors: Frank Stegmeier; Guang Hu; Richard J Rickles; Gregory J Hannon; Stephen J Elledge
Journal: Proc Natl Acad Sci U S A Date: 2005-09-01 Impact factor: 11.205

Review 3. PKR--a protein kinase regulated by double-stranded RNA.

Authors: M J Clemens
Journal: Int J Biochem Cell Biol Date: 1997-07 Impact factor: 5.085

4. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

Authors: Oded Singer; Robert A Marr; Edward Rockenstein; Leslie Crews; Nicole G Coufal; Fred H Gage; Inder M Verma; Eliezer Masliah
Journal: Nat Neurosci Date: 2005-08-28 Impact factor: 24.884

5. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.

Authors: G Scott Ralph; Pippa A Radcliffe; Denise M Day; Janine M Carthy; Marie A Leroux; Debbie C P Lee; Liang-Fong Wong; Lynsey G Bilsland; Linda Greensmith; Susan M Kingsman; Kyriacos A Mitrophanous; Nicholas D Mazarakis; Mimoun Azzouz
Journal: Nat Med Date: 2005-03-13 Impact factor: 53.440

6. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

Authors: Cédric Raoul; Toufik Abbas-Terki; Jean-Charles Bensadoun; Sandrine Guillot; Georg Haase; Jolanta Szulc; Christopher E Henderson; Patrick Aebischer
Journal: Nat Med Date: 2005-03-13 Impact factor: 53.440

7. Development of a self-inactivating lentivirus vector.

Authors: H Miyoshi; U Blömer; M Takahashi; F H Gage; I M Verma
Journal: J Virol Date: 1998-10 Impact factor: 5.103

8. Efficient production of germline transgenic chickens using lentiviral vectors.

Authors: Michael J McGrew; Adrian Sherman; Fiona M Ellard; Simon G Lillico; Hazel J Gilhooley; Alan J Kingsman; Kyriacos A Mitrophanous; Helen Sang
Journal: EMBO Rep Date: 2004-06-11 Impact factor: 8.807

9. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

Authors: Haibin Xia; Qinwen Mao; Steven L Eliason; Scott Q Harper; Inês H Martins; Harry T Orr; Henry L Paulson; Linda Yang; Robert M Kotin; Beverly L Davidson
Journal: Nat Med Date: 2004-07-04 Impact factor: 53.440

10. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.

Authors: L Naldini; U Blömer; P Gallay; D Ory; R Mulligan; F H Gage; I M Verma; D Trono
Journal: Science Date: 1996-04-12 Impact factor: 47.728

31 in total

Review 1. A primer on using pooled shRNA libraries for functional genomic screens.

Authors: Guang Hu; Ji Luo
Journal: Acta Biochim Biophys Sin (Shanghai) Date: 2012-02 Impact factor: 3.848

Review 2. New routes for transgenesis of the mouse.

Authors: José E Belizário; Priscilla Akamini; Philip Wolf; Bryan Strauss; José Xavier-Neto
Journal: J Appl Genet Date: 2012-05-09 Impact factor: 3.240

3. Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke.

Authors: Abdelrahman Y Fouda; Ahmed Alhusban; Tauheed Ishrat; Bindu Pillai; Wael Eldahshan; Jennifer L Waller; Adviye Ergul; Susan C Fagan
Journal: Mol Neurobiol Date: 2016-01-12 Impact factor: 5.590

4. Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice.

Authors: Po-Chuan Shen; Chia-Sing Lu; Ai-Li Shiau; Che-Hsin Lee; I-Ming Jou; Jeng-Long Hsieh
Journal: Hum Gene Ther Date: 2013-10 Impact factor: 5.695