OBJECTIVE: To characterize the co-existence of multiple pain-related complaints in patients enrolled in a series of pharmaceutical company drug trials for the treatment of Major Depressive Disorder (MDD). METHOD: Pooled 'blinded' data from 2191 patients enrolled in randomized, multicenter, double-blind placebo-controlled studies for the treatment of MDD were analyzed. Painful symptoms were assessed using the seven pain symptoms subset of the Somatic Symptoms Inventory: 'Headache,' 'Pain in lower back,' 'Neck pain,' 'Pain in joints,' 'Soreness in muscles,' 'Pain in heart or chest,' and 'Pain or cramps in abdomen.' The 17-item Hamilton Depression Rating Scale (HAMD) was used to assess severity of depression. RESULTS: Of those meeting the study entry criteria (total HAMD score >or=15), 25% reported no pain complaints and 18% reported 1 pain compliant; the majority (57%) of patients reported the co-existence of multiple pain-related complaints, with 14%, 12%, 11%, 11%, 7%, and 3% of patients reporting 2, 3, 4, 5, 6 and 7 different pain symptoms, respectively. The number of pain-related symptoms experienced was moderately related to severity of depression (r = 0.35), with the most common pain symptom combinations being among headaches, lower back pain, neck pain, pain in joints, and soreness in muscles. CONCLUSIONS: This study supports pain as a component feature of MDD. The number of comorbid pain-related complaints, which generally increased as a function of depressive severity, should be considered in the diagnosis of depression, planning of treatment strategies, and measurement of treatment outcome.
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OBJECTIVE: To characterize the co-existence of multiple pain-related complaints in patients enrolled in a series of pharmaceutical company drug trials for the treatment of Major Depressive Disorder (MDD). METHOD: Pooled 'blinded' data from 2191 patients enrolled in randomized, multicenter, double-blind placebo-controlled studies for the treatment of MDD were analyzed. Painful symptoms were assessed using the seven pain symptoms subset of the Somatic Symptoms Inventory: 'Headache,' 'Pain in lower back,' 'Neck pain,' 'Pain in joints,' 'Soreness in muscles,' 'Pain in heart or chest,' and 'Pain or cramps in abdomen.' The 17-item Hamilton Depression Rating Scale (HAMD) was used to assess severity of depression. RESULTS: Of those meeting the study entry criteria (total HAMD score >or=15), 25% reported no pain complaints and 18% reported 1 pain compliant; the majority (57%) of patients reported the co-existence of multiple pain-related complaints, with 14%, 12%, 11%, 11%, 7%, and 3% of patients reporting 2, 3, 4, 5, 6 and 7 different pain symptoms, respectively. The number of pain-related symptoms experienced was moderately related to severity of depression (r = 0.35), with the most common pain symptom combinations being among headaches, lower back pain, neck pain, pain in joints, and soreness in muscles. CONCLUSIONS: This study supports pain as a component feature of MDD. The number of comorbid pain-related complaints, which generally increased as a function of depressive severity, should be considered in the diagnosis of depression, planning of treatment strategies, and measurement of treatment outcome.
Authors: Anthony L Vaccarino; Kenneth R Evans; Amir H Kalali; Sidney H Kennedy; Nina Engelhardt; Benicio N Frey; John H Greist; Kenneth A Kobak; Raymond W Lam; Glenda MacQueen; Roumen Milev; Franca M Placenza; Arun V Ravindran; David V Sheehan; Terrence Sills; Janet B W Williams Journal: Innov Clin Neurosci Date: 2016-10-01
Authors: Anthony L Vaccarino; Amir H Kalali; Pierre Blier; Susan Gilbert Evans; Nina Engelhardt; Jane A Foster; Benicio N Frey; John H Greist; Kenneth A Kobak; Raymond W Lam; Glenda MacQueen; Roumen Milev; Daniel J Müller; Sagar V Parikh; Franca M Placenza; Sakina J Rizvi; Susan Rotzinger; David V Sheehan; Terrence Sills; Claudio N Soares; Gustavo Turecki; Rudolph Uher; Janet B W Williams; Sidney H Kennedy; Kenneth R Evans Journal: Innov Clin Neurosci Date: 2020-07-01
Authors: Madeline H Meier; Nathan A Gillespie; Narelle K Hansell; Alex W Hewitt; Ian B Hickie; Yi Lu; Stuart MacGregor; Sarah E Medland; Cong Sun; Tien Y Wong; Margaret J Wright; Gu Zhu; Nicholas G Martin; David A Mackey Journal: Psychosom Med Date: 2014 Nov-Dec Impact factor: 4.312
Authors: W Eich; W Häuser; B Arnold; W Jäckel; M Offenbächer; F Petzke; M Schiltenwolf; M Settan; C Sommer; T Tölle; N Uçeyler; P Henningsen Journal: Schmerz Date: 2012-06 Impact factor: 1.107