Literature DB >> 19073714

Building a knowledge base for systems pathology.

Holger Michael1, Jennifer Hogan, Alexander Kel, Olga Kel-Margoulis, Frank Schacherer, Nico Voss, Edgar Wingender.   

Abstract

Translating the exponentially growing amount of omics data into knowledge usable for a personalized medicine approach poses a formidable challenge. In this article-taking diabetes as a use case-we present strategies for developing data repositories into computer-accessible knowledge sources that can be used for a systemic view on the molecular causes of diseases, thus laying the foundation for systems pathology.

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Year:  2008        PMID： 19073714     DOI： 10.1093/bib/bbn038

Source DB:  PubMed          Journal:  Brief Bioinform        ISSN： 1467-5463            Impact factor:   11.622


  7 in total

1.  Molecular mechanistic associations of human diseases.

Authors:  Philip Stegmaier; Mathias Krull; Nico Voss; Alexander E Kel; Edgar Wingender
Journal:  BMC Syst Biol       Date:  2010-09-06

2.  Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer.

Authors:  Philip Stegmaier; Nico Voss; Tatiana Meier; Alexander Kel; Edgar Wingender; Juergen Borlak
Journal:  PLoS One       Date:  2011-03-28       Impact factor: 3.240

3.  "Upstream Analysis": An Integrated Promoter-Pathway Analysis Approach to Causal Interpretation of Microarray Data.

Authors:  Jeannette Koschmann; Anirban Bhar; Philip Stegmaier; Alexander E Kel; Edgar Wingender
Journal:  Microarrays (Basel)       Date:  2015-05-21

4.  Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3.

Authors:  Ulyana Boyarskikh; Sergey Pintus; Nikita Mandrik; Daria Stelmashenko; Ilya Kiselev; Ivan Evshin; Ruslan Sharipov; Philip Stegmaier; Fedor Kolpakov; Maxim Filipenko; Alexander Kel
Journal:  BMC Med Genomics       Date:  2018-02-13       Impact factor: 3.063

5.  BioUML: an integrated environment for systems biology and collaborative analysis of biomedical data.

Authors:  Fedor Kolpakov; Ilya Akberdin; Timur Kashapov; Llya Kiselev; Semyon Kolmykov; Yury Kondrakhin; Elena Kutumova; Nikita Mandrik; Sergey Pintus; Anna Ryabova; Ruslan Sharipov; Ivan Yevshin; Alexander Kel
Journal:  Nucleic Acids Res       Date:  2019-07-02       Impact factor: 16.971

6.  Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis.

Authors:  Alexander N Orekhov; Yumiko Oishi; Nikita G Nikiforov; Andrey V Zhelankin; Larisa Dubrovsky; Igor A Sobenin; Alexander Kel; Daria Stelmashenko; Vsevolod J Makeev; Kathy Foxx; Xueting Jin; Howard S Kruth; Michael Bukrinsky
Journal:  Curr Pharm Des       Date:  2018       Impact factor: 3.116

7.  Multi-omics "upstream analysis" of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer.

Authors:  Alexander E Kel; Philip Stegmaier; Tagir Valeev; Jeannette Koschmann; Vladimir Poroikov; Olga V Kel-Margoulis; Edgar Wingender
Journal:  EuPA Open Proteom       Date:  2016-09-09
  7 in total

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