Electrophysiological characteristics of orthodromic reentrant tachycardia in patients with Wolf-Parkinson-White syndrome and atrial fibrillation.

The aim of this study was to evaluate differences in the electrophysiological features of atrioventricular reentrant tachycardia (AVRT) in patients with Wolf-Parkinson-White syndrome (WPW) associated with or without atrial fibrillation (AF). We included 119 patients with WPW and orthodromic AVRT during electrophysiological study. The patients were divided into two groups; group I with documented episodes of AF (n=39, mean age 33.3+/-11.5 years), and group II without AF (n=80, mean age 35.3+/-13.8). We compared parameters of accessory pathway (AP), atrium and ventricle between two groups and found no significant difference. We next assessed the electrophysiological parameters of AVRT in both groups in terms of conduction times and atrioventricular (AV) activation relations. A significant negative correlation was found in group II between anterograde and retrograde conduction times measured as AV and VA intervals at the site of the earliest atrial activation (r=-0.43, P<0.0001), whereas no significant correlation was seen in group I (r=-0.29, P=0.1). Comparative analysis between two groups revealed significant difference in A-V/V-V index (P=0.05). These data suggest the presence of different electrophysiological properties of AP during AVRT in only few respects in patients with AF compared to those without it. Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.