| Literature DB >> 19072540 |
William J Moore1, Jeffrey C Kern, Ramesh Bhat, Thomas J Commons, Shoichi Fukayama, Igor Goljer, Girija Krishnamurthy, Ronald L Magolda, Lisa Nogle, Keith Pitts, Barb Stauffer, Eugene J Trybulski, Gregory S Welmaker, Matthew Wilson, Peter V N Bodine.
Abstract
The diphenylsulfonyl sulfonamide scaffold represented by 1 (WAY-316606) are small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-related disorders. Details of the structure-activity relationships and biological activity from the first structural class of this scaffold will be discussed.Entities:
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Year: 2009 PMID： 19072540 DOI： 10.1021/jm801144h
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446