Possible role for G-proteins in behavioral sensitization to cocaine.

The role of G-proteins in behavioral sensitization to cocaine was examined by injecting pertussis toxin (PTX) into the A10 dopamine cell group. The capacity of acute cocaine to increase motor activity and dopamine release in the nucleus accumbens was significantly augmented in rats pretreated 14 days earlier with PTX. These data suggest that injection of PTX into the A10 dopamine cell group produces a long-term alteration in mesolimbic dopamine function, and implicates A10 dopamine neurons and G-proteins in the development of behavioral sensitization.