Literature DB >> 19071177

The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine.

Rana Chattopadhyay1, Solomon Conteh, Minglin Li, Eric R James, Judith E Epstein, Stephen L Hoffman.   

Abstract

We are developing a radiation attenuated Plasmodium falciparum sporozoite (PfSPZ) malaria vaccine. An important step was to determine the minimum dose of irradiation required to adequately attenuate each sporozoite. This was studied in the Plasmodium yoelii rodent model system. Exposure to 100 Gy completely attenuated P. yoelii sporozoites (PySPZ). Next we demonstrated that immunization of mice intravenously with 3 doses of 750 PySPZ that had received 200 Gy, double the radiation dose required for attenuation, resulted in 100% protection. These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses.

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Year:  2008        PMID： 19071177     DOI： 10.1016/j.vaccine.2008.11.073

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  20 in total

1.  Neither mosquito saliva nor immunity to saliva has a detectable effect on the infectivity of Plasmodium sporozoites injected into mice.

Authors:  Chahnaz Kebaier; Tatiana Voza; Jerome Vanderberg
Journal:  Infect Immun       Date:  2009-11-02       Impact factor: 3.441

2.  Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.

Authors:  Noah S Butler; Nathan W Schmidt; Ashley M Vaughan; Ahmed S Aly; Stefan H I Kappe; John T Harty
Journal:  Cell Host Microbe       Date:  2011-06-16       Impact factor: 21.023

3.  Trimethoprim-Sulfamethoxazole Prophylaxis During Live Malaria Sporozoite Immunization Induces Long-Lived, Homologous, and Heterologous Protective Immunity Against Sporozoite Challenge.

Authors:  Charlotte V Hobbs; Charles Anderson; Jillian Neal; Tejram Sahu; Solomon Conteh; Tatiana Voza; Jean Langhorne; William Borkowsky; Patrick E Duffy
Journal:  J Infect Dis       Date:  2016-10-17       Impact factor: 5.226

4.  CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii.

Authors:  Katherine L Doll; Noah S Butler; John T Harty
Journal:  Vaccine       Date:  2013-12-07       Impact factor: 3.641

5.  Advances and challenges in malaria vaccine development.

Authors:  Ruobing Wang; Joseph D Smith; Stefan H I Kappe
Journal:  Expert Rev Mol Med       Date:  2009-12-16       Impact factor: 5.600

Review 6.  Genetically engineered, attenuated whole-cell vaccine approaches for malaria.

Authors:  Ashley M Vaughan; Ruobing Wang; Stefan H I Kappe
Journal:  Hum Vaccin       Date:  2010-01-29

7.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

8.  Plasmodium yoelii-infected A. stephensi inefficiently transmit malaria compared to intravenous route.

Authors:  Solomon Conteh; Rana Chattopadhyay; Charles Anderson; Stephen L Hoffman
Journal:  PLoS One       Date:  2010-01-28       Impact factor: 3.240

9.  Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

Authors:  Nathan W Schmidt; Noah S Butler; Vladimir P Badovinac; John T Harty
Journal:  PLoS Pathog       Date:  2010-07-15       Impact factor: 6.823

10.  Radiation-induced cellular and molecular alterations in asexual intraerythrocytic Plasmodium falciparum.

Authors:  Miranda S Oakley; Noel Gerald; Vivek Anantharaman; Yamei Gao; Victoria Majam; Babita Mahajan; Phuong Thao Pham; Leda Lotspeich-Cole; Timothy G Myers; Thomas F McCutchan; Sheldon L Morris; L Aravind; Sanjai Kumar
Journal:  J Infect Dis       Date:  2012-10-24       Impact factor: 5.226
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