Literature DB >> 19070571

Collateral damage from antigen receptor gene diversification.

Grace K Mahowald1, Jason M Baron, Barry P Sleckman.   

Abstract

Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs.

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Year:  2008        PMID： 19070571     DOI： 10.1016/j.cell.2008.11.024

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  16 in total

1.  Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice.

Authors:  Alice Nemajerova; Oleksi Petrenko; Lorenz Trümper; Gustavo Palacios; Ute M Moll
Journal:  J Clin Invest       Date:  2010-05-17       Impact factor: 14.808

2.  Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity.

Authors:  Christina A Gerodimos; Howard H Y Chang; Go Watanabe; Michael R Lieber
Journal:  J Biol Chem       Date:  2017-07-10       Impact factor: 5.157

3.  Increased frequency of micronuclei in lymphocytes of infertile males after exposure to gamma irradiation: a possible sign of genomic instability.

Authors:  Sahar Moghbeli-Nejad; Hossein Mozdarani; Ashraf Aleyasin
Journal:  J Assist Reprod Genet       Date:  2011-03-02       Impact factor: 3.412

Review 4.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Authors:  Michael R Lieber
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

5.  Genome instability in AZFc region on Y chromosome in leukocytes of fertile and infertile individuals following exposure to gamma radiation.

Authors:  Sahar Moghbeli-Nejad; Hossein Mozdarani; Mehrdad Behmanesh; Zahra Rezaiean; Parvin Fallahi
Journal:  J Assist Reprod Genet       Date:  2011-09-06       Impact factor: 3.412

Review 6.  Mechanisms of chromosomal rearrangement in the human genome.

Authors:  Albert G Tsai; Michael R Lieber
Journal:  BMC Genomics       Date:  2010-02-10       Impact factor: 3.969

7.  Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.

Authors:  Grace K Mahowald; Jason M Baron; Michael A Mahowald; Shashikant Kulkarni; Andrea L Bredemeyer; Craig H Bassing; Barry P Sleckman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-09       Impact factor: 11.205

8.  Mechanisms promoting translocations in editing and switching peripheral B cells.

Authors:  Jing H Wang; Monica Gostissa; Catherine T Yan; Peter Goff; Thomas Hickernell; Erica Hansen; Simone Difilippantonio; Duane R Wesemann; Ali A Zarrin; Klaus Rajewsky; Andre Nussenzweig; Frederick W Alt
Journal:  Nature       Date:  2009-07-09       Impact factor: 49.962

9.  Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation.

Authors:  Xiaoping Cui; Zhengfei Lu; Aya Kurosawa; Lars Klemm; Andrew T Bagshaw; Albert G Tsai; Neil Gemmell; Markus Müschen; Noritaka Adachi; Chih-Lin Hsieh; Michael R Lieber
Journal:  Mol Cell Biol       Date:  2012-12-21       Impact factor: 4.272

Review 10.  Mechanisms of human lymphoid chromosomal translocations.

Authors:  Michael R Lieber
Journal:  Nat Rev Cancer       Date:  2016-05-25       Impact factor: 60.716
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