Literature DB >> 19070486

3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.

Robert T Hendricks1, Stacey R Spencer, James F Blake, Jay B Fell, John P Fischer, Peter J Stengel, Vincent J P Leveque, Sophie Lepogam, Sonal Rajyaguru, Isabel Najera, John A Josey, Steven Swallow.   

Abstract

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.

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Year:  2008        PMID： 19070486     DOI： 10.1016/j.bmcl.2008.11.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.

Authors:  Alan Rolfe; Thiwanka B Samarakoon; Sarra V Klimberg; Marek Brzozowski; Benjamin Neuenswander; Gerald H Lushington; Paul R Hanson
Journal:  J Comb Chem       Date:  2010-09-29

2.  Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides.

Authors:  Daniel A Everson; Joseph A Buonomo; Daniel J Weix
Journal:  Synlett       Date:  2014-01       Impact factor: 2.454

3.  One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acids.

Authors:  Alan Rolfe; Kyle Young; Kelly Volp; Frank Schoenen; Benjamin Neuenswander; Gerald H Lushington; Paul R Hanson
Journal:  J Comb Chem       Date:  2009 Jul-Aug

4.  Allosteric inhibitors have distinct effects, but also common modes of action, in the HCV polymerase.

Authors:  Brittny C Davis; Jodian A Brown; Ian F Thorpe
Journal:  Biophys J       Date:  2015-04-07       Impact factor: 4.033
  4 in total

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