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Literature DB >> 19070454

Combination of different molecular mechanisms leading to fluconazole resistance in a Candida lusitaniae clinical isolate.

David Reboutier¹, Mathieu Piednoël, Stéphanie Boisnard, Audrey Conti, Virginie Chevalier, Martine Florent, Stéphanie Gibot-Leclerc, Bruno Da Silva, Christiane Chastin, Karim Fallague, Anne Favel, Thierry Noël, Gwenaël Ruprich-Robert, Florence Chapeland-Leclerc, Nicolas Papon.

Abstract

We report on the underlying molecular mechanisms likely responsible for the high-level fluconazole resistance in a Candida lusitaniae clinical isolate. Fluconazole resistance correlated with overexpression of ERG11 and of several efflux pump genes, in particular, the orthologs of the Candida albicans MDR1, PDR16, CDR1, CDR2, and YOR1.

Entities: Chemical Species

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Year: 2008 PMID： 19070454 DOI： 10.1016/j.diagmicrobio.2008.10.019

Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803

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Cited

8 in total

1. Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy.

Authors: Sandra A Asner; Stefano Giulieri; Manuel Diezi; Oscar Marchetti; Dominique Sanglard
Journal: Antimicrob Agents Chemother Date: 2015-10-05 Impact factor: 5.191

2. Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.

Authors: Frédéric Gabriel; Ayman Sabra; Sofiane El-Kirat-Chatel; Sophie Pujol; Valérie Fitton-Ouhabi; Daniel Brèthes; Karine Dementhon; Isabelle Accoceberry; Thierry Noël
Journal: Antimicrob Agents Chemother Date: 2014-05-27 Impact factor: 5.191

3. Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal-macrophage interaction.

Authors: Eric H Jung; Yoon-Dong Park; Quigly Dragotakes; Lia S Ramirez; Daniel Q Smith; Flavia C G Reis; Amanda Dziedzic; Marcio L Rodrigues; Rosanna P Baker; Peter R Williamson; Anne Jedlicka; Arturo Casadevall; Carolina Coelho
Journal: Microlife Date: 2022-09-21

Combination of different molecular mechanisms leading to fluconazole resistance in a Candida lusitaniae clinical isolate.

1. Acquired Multidrug Antifungal Resistance in Candida lusitaniae during Therapy.

2. Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.

3. Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal-macrophage interaction.

4. New diphenylphosphane derivatives of ketoconazole are promising antifungal agents.

5. Carveoylphenols and Their Antifungal Potential against Pathogenic Yeasts.

6. Comparative Genomics for the Elucidation of Multidrug Resistance in Candida lusitaniae.

7. Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1.

8. Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection.