Literature DB >> 19070282

Medical management of toxicological mass casualty events.

Gal Markel1, Amir Krivoy, Eran Rotman, Ophir Schein, Shai Shrot, Tal Brosh-Nissimov, Tsvika Dushnitsky, Arik Eisenkraft.   

Abstract

The relative accessibility to various chemical agents, including chemical warfare agents and toxic industrial compounds, places a toxicological mass casualty event, including chemical terrorism, among the major threats to homeland security. TMCE represents a medical and logistic challenge with potential hazardous exposure of first-response teams. In addition, TMCE poses substantial psychological and economic impact. We have created a simple response algorithm that provides practical guidelines for participating forces in TMCE. Emphasis is placed on the role of first responders, highlighting the importance of early recognition of the event as a TMCE, informing the command and control centers, and application of appropriate self-protection. The medical identification of the toxidrome is of utmost importance as it may dictate radically different approaches and life-saving modalities. Our proposed emergency management of TMCE values the "Scoop & Run" approach orchestrated by an organized evacuation plan rather than on-site decontamination. Finally, continuous preparedness of health systems - exemplified by periodic CBRN (Chemical, Biological, Radio-Nuclear) medical training of both first responders and hospital staff, mandatory placement of antidotal auto-injectors in all ambulances and CBRN emergency kits in the emergency departments - would considerably improve the emergency medical response to TMCE.

Entities:  

Mesh:

Year:  2008        PMID: 19070282

Source DB:  PubMed          Journal:  Isr Med Assoc J            Impact factor:   0.892


  6 in total

1.  Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus.

Authors:  Valery Golderman; Efrat Shavit-Stein; Orna Gera; Joab Chapman; Arik Eisenkraft; Nicola Maggio
Journal:  J Mol Neurosci       Date:  2018-12-04       Impact factor: 3.444

Review 2.  Possible role for anisodamine in organophosphate poisoning.

Authors:  Arik Eisenkraft; Avshalom Falk
Journal:  Br J Pharmacol       Date:  2016-04-22       Impact factor: 8.739

Review 3.  The role of glutamate and the immune system in organophosphate-induced CNS damage.

Authors:  Arik Eisenkraft; Avshalom Falk; Arseny Finkelstein
Journal:  Neurotox Res       Date:  2013-03-27       Impact factor: 3.911

4.  Biphasic cuirass ventilation is better than bag-valve mask ventilation for resuscitation following organophosphate poisoning.

Authors:  Ilan Gur; Shlomo Shapira; Shahaf Katalan; Amir Rosner; Shlomo Baranes; Ettie Grauer; Jacob Moran-Gilad; Arik Eisenkraft
Journal:  Toxicol Rep       Date:  2014-11-24

5.  The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro.

Authors:  Valery Golderman; Efrat Shavit-Stein; Ilia Tamarin; Yossi Rosman; Shai Shrot; Nurit Rosenberg; Nicola Maggio; Joab Chapman; Arik Eisenkraft
Journal:  PLoS One       Date:  2016-09-30       Impact factor: 3.240

6.  Maintaining Preparedness to Severe Though Infrequent Threats-Can It Be Done?

Authors:  Maya Siman-Tov; Benny Davidson; Bruria Adini
Journal:  Int J Environ Res Public Health       Date:  2020-03-31       Impact factor: 3.390

  6 in total

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