Literature DB >> 19069245

The effect of some 1-[4-(2-diethylaminoethoxy)phenylcarbonyl]-3,5-bis (benzylidene)-4-piperidone methiodides and related compounds on respiration and swelling of rat liver mitochondria.

S Das1, U Das, B Bandy, D K J Gorecki, J R Dimmock.   

Abstract

The effect of a number of N-aroyl-3,5-bis(benzylidene)-4-piperidones 2 and related quaternary ammonium compounds 3 on the rates of respiration in rat liver mitochondria were determined. All of the compounds stimulated respiration and the greatest effect was displayed by the compounds in series 3 which caused swelling of mitochondria.

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Year:  2008        PMID： 19069245      PMCID： PMC3346743     

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  7 in total

1.  Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2+ ions. A proposed model for phosphate-stimulated lipid peroxidation.

Authors:  A J Kowaltowski; R F Castilho; M T Grijalba; E J Bechara; A E Vercesi
Journal:  J Biol Chem       Date:  1996-02-09       Impact factor: 5.157

2.  Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.

Authors:  Umashankar Das; Jane Alcorn; Anuraag Shrivastav; Rajendra K Sharma; Erik De Clercq; Jan Balzarini; Jonathan R Dimmock
Journal:  Eur J Med Chem       Date:  2006-09-22       Impact factor: 6.514

3.  A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.

Authors:  J R Dimmock; M P Padmanilayam; R N Puthucode; A J Nazarali; N L Motaganahalli; G A Zello; J W Quail; E O Oloo; H B Kraatz; J S Prisciak; T M Allen; C L Santos; J Balzarini; E De Clercq; E K Manavathu
Journal:  J Med Chem       Date:  2001-02-15       Impact factor: 7.446

4.  Synergistic inhibition of mitochondrial respiration by anticancer agent erucylphosphohomocholine and cyclosporin A.

Authors:  Victor V Lemeshko; Wilfried Kugler
Journal:  J Biol Chem       Date:  2007-11-09       Impact factor: 5.157

5.  N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents.

Authors:  Umashankar Das; Swagatika Das; Brian Bandy; James P Stables; Jonathan R Dimmock
Journal:  Bioorg Med Chem       Date:  2008-02-08       Impact factor: 3.641

6.  Toxic effects of copper-based antineoplastic drugs (Casiopeinas) on mitochondrial functions.

Authors:  Alvaro Marín-Hernández; Isabel Gracia-Mora; Lena Ruiz-Ramírez; Rafael Moreno-Sánchez
Journal:  Biochem Pharmacol       Date:  2003-06-15       Impact factor: 5.858

7.  Effect of 4-dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen-3-one hydrochloride and related compounds on respiration in rat liver mitochondria.

Authors:  N W Hamon; D L Kirkpatrick; E W Chow; J R Dimmock
Journal:  J Pharm Sci       Date:  1982-01       Impact factor: 3.534
  7 in total
  2 in total

Review 1.  1,5-diaryl-3-oxo-1,4-pentadienes: a case for antineoplastics with multiple targets.

Authors:  U Das; R K Sharma; J R Dimmock
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

2.  3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and related diethyl esters: Potent cytotoxins with multi-drug-resistance reverting properties.

Authors:  Swagatika Das; Umashankar Das; Ponniah Selvakumar; Rajendra K Sharma; Jan Balzarini; Erik De Clercq; Joseph Molnár; Julianna Serly; Zoltán Baráth; Gabriele Schatte; Brian Bandy; Dennis K J Gorecki; Jonathan R Dimmock
Journal:  ChemMedChem       Date:  2009-11       Impact factor: 3.466
  2 in total

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