OBJECTIVE: To compare performance of conventional Pap test, liquid based cytology (LBC) and visual inspection with acetic acid (VIA), as well as human papillomavirus (HPV) testing in 2 subcohorts of women, <35 and > or =35 years of age. STUDY DESIGN: Performance indicators were calculated using colposcopic biopsies as the gold standard; all results were corrected for verification bias using maximum likelihood. RESULT: Both conventional Pap test n d Hybrid Capture 2 (HC2) assay performed significantly better among older women than younger; no difference was observed in performance of LBC and VIA, both inferior to Pap and HC2. The Pap test was more specific than HC2 in both subcohorts; HC2 had the highest sensitivity. For individual tests, the best balance between sensitivity and specificity was obtained for HC2 assay corrected for verification bias in the older women's subcohort; this was further improved by the combined use of the Pap test and HC2. CONCLUSION: Age of the target population is an important determinant of the performance of different screening tests. The choice of optimal test for women <35 and > or =35 years of age depends on whether the highest positive predictive value (Pap test).
OBJECTIVE: To compare performance of conventional Pap test, liquid based cytology (LBC) and visual inspection with acetic acid (VIA), as well as human papillomavirus (HPV) testing in 2 subcohorts of women, <35 and > or =35 years of age. STUDY DESIGN: Performance indicators were calculated using colposcopic biopsies as the gold standard; all results were corrected for verification bias using maximum likelihood. RESULT: Both conventional Pap test n d Hybrid Capture 2 (HC2) assay performed significantly better among older women than younger; no difference was observed in performance of LBC and VIA, both inferior to Pap and HC2. The Pap test was more specific than HC2 in both subcohorts; HC2 had the highest sensitivity. For individual tests, the best balance between sensitivity and specificity was obtained for HC2 assay corrected for verification bias in the older women's subcohort; this was further improved by the combined use of the Pap test and HC2. CONCLUSION: Age of the target population is an important determinant of the performance of different screening tests. The choice of optimal test for women <35 and > or =35 years of age depends on whether the highest positive predictive value (Pap test).
Authors: Jenell S Coleman; Michelle S Cespedes; Susan Cu-Uvin; Rose J Kosgei; May Maloba; Jean Anderson; Timothy Wilkin; Antoine Jaquet; Julia Bohlius; Kathryn Anastos; Kara Wools-Kaloustian Journal: J Low Genit Tract Dis Date: 2016-01 Impact factor: 1.925
Authors: Adhemar Longatto-Filho; Paulo Naud; Sophie Fm Derchain; Cecília Roteli-Martins; Sílvio Tatti; Luciano Serpa Hammes; Luis Otavio Sarian; Mojca Eržen; Margherita Branca; Jean Carlos de Matos; Renata Gontijo; Marina Y S Maeda; Temístocles Lima; Silvano Costa; Stina Syrjänen; Kari Syrjänen Journal: Virchows Arch Date: 2012-05-05 Impact factor: 4.064
Authors: Y Tong; E Orang'o; M Nakalembe; P Tonui; P Itsura; K Muthoka; M Titus; S Kiptoo; A Mwangi; J Ong'echa; R Tonui; B Odongo; C Mpamani; B Rosen; A Moormann; S Cu-Uvin; J A Bailey; C I Oduor; A Ermel; C Yiannoutsos; B Musick; E Sang; A Ngeresa; G Banturaki; A Kiragga; J Zhang; Y Song; S Chintala; R Katzenellenbogen; P Loehrer; D R Brown Journal: Ann Med Date: 2022-12 Impact factor: 5.348