Literature DB >> 19068

Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. I. An analysis of anomalous reactivation kinetics.

J W Hovanec, C A Broomfield, G M Steinberg, K W Lanks, C N Lieske.   

Abstract

The first kinetic studies on the spontaneous reactivation of Sarin-inhibited acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) are reported. With increasing pH the extent of reactivation increases while the observed rate constant decreases. An analysis of the change in aging rate constant as a function of pH suggests that the aging of alkyl-alkoxy phosphonylated acetylcholinesterases is not solely acid catalyzed.

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Year:  1977        PMID： 19068     DOI： 10.1016/0005-2744(77)90059-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  3 in total

1.  Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis.

Authors:  Kirstin P Hester; Krishna Bhattarai; Haobo Jiang; Pratul K Agarwal; Carey Pope
Journal:  Chem Res Toxicol       Date:  2019-08-28       Impact factor: 3.739

2.  Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.

Authors:  Chih-Kai Chao; S Kaleem Ahmed; John M Gerdes; Charles M Thompson
Journal:  Chem Res Toxicol       Date:  2016-10-17       Impact factor: 3.739

3.  Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Authors:  Andrew C Hemmert; Tamara C Otto; Roberto A Chica; Monika Wierdl; Jonathan S Edwards; Steven M Lewis; Steven L Lewis; Carol C Edwards; Lyudmila Tsurkan; C Linn Cadieux; Shane A Kasten; John R Cashman; Stephen L Mayo; Philip M Potter; Douglas M Cerasoli; Matthew R Redinbo
Journal:  PLoS One       Date:  2011-03-18       Impact factor: 3.240
  3 in total

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