Literature DB >> 19067913

Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet.

Petr Hubacek1, Petra Keslova, Renata Formankova, Pavel Pochop, Ondrej Cinek, Miroslav Zajac, Jana Lochmanova, Jan Stary, Petr Sedlacek.   

Abstract

We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19067913     DOI： 10.1111/j.1399-3046.2008.01070.x

Source DB:  PubMed          Journal:  Pediatr Transplant        ISSN： 1397-3142


  5 in total

1.  A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations.

Authors:  Toshihiro Matsukawa; Hideki Goto; Kenta Takahashi; Shinsuke Asanuma; Atsushi Yasumoto; Mutsumi Takahata; Akio Shigematsu; Tomoyuki Endo; Junji Tanaka; Satoshi Hashino; Shinya Tanaka; Masahiro Imamura
Journal:  Int J Hematol       Date:  2012-01-20       Impact factor: 2.490

Review 2.  Opportunistic infections of the central nervous system in the transplant patient.

Authors:  Bruce A Cohen; Valentina Stosor
Journal:  Curr Neurol Neurosci Rep       Date:  2013-09       Impact factor: 5.081

3.  Severe CMV complication following maintenance therapy with rituximab.

Authors:  Lenaïg Le Clech; Jean-Christophe Ianotto; Isabelle Quintin-Roue; Adrian Tempescul
Journal:  BMJ Case Rep       Date:  2013-01-09

4.  CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)-Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

Authors:  M Schmidt-Hieber; G Silling; E Schalk; W Heinz; J Panse; O Penack; M Christopeit; D Buchheidt; U Meyding-Lamadé; S Hähnel; H H Wolf; M Ruhnke; S Schwartz; G Maschmeyer
Journal:  Ann Oncol       Date:  2016-04-06       Impact factor: 32.976

5.  Temporal and spatial compartmentalization of drug-resistant cytomegalovirus (CMV) in a child with CMV meningoencephalitis: implications for sampling in molecular diagnosis.

Authors:  Pierre Frange; David Boutolleau; Marianne Leruez-Ville; Fabien Touzot; Guilhem Cros; Sebastien Heritier; Despina Moshous; Benedicte Neven; Alain Fischer; Stephane Blanche
Journal:  J Clin Microbiol       Date:  2013-10-09       Impact factor: 5.948
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.