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Literature DB >> 1906767

Pinacidil inhibits the ryanodine-sensitive outward current and glibenclamide antagonizes its action in cells from the rabbit portal vein.

Z L Xiong¹, S Kajioka, T Sakai, K Kitamura, H Kuriyama.

Abstract

Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.

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Year: 1991 PMID： 1906767 PMCID： PMC1917986 DOI： 10.1111/j.1476-5381.1991.tb12252.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

1. Regulation of the ATP-sensitive potassium channel.

Authors: J R de Weille; M Lazdunski
Journal: Ion Channels Date: 1990

2. Pinacidil activates the ATP-sensitive K+ channel in inside-out and cell-attached patch membranes of guinea-pig ventricular myocytes.

Authors: Z Fan; K Nakayama; M Hiraoka
Journal: Pflugers Arch Date: 1990-01 Impact factor: 3.657

3. Properties of calcium stores and transient outward currents in single smooth muscle cells of rabbit intestine.

Authors: T B Bolton; S P Lim
Journal: J Physiol Date: 1989-02 Impact factor: 5.182

4. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.

Authors: N B Standen; J M Quayle; N W Davies; J E Brayden; Y Huang; M T Nelson
Journal: Science Date: 1989-07-14 Impact factor: 47.728

5. Actions of cromakalim on ionic currents recorded from single smooth muscle cells of the rat portal vein.

Authors: K Okabe; S Kajioka; K Nakao; K Kitamura; H Kuriyama; A H Weston
Journal: J Pharmacol Exp Ther Date: 1990-02 Impact factor: 4.030

6. Nicorandil opens a calcium-dependent potassium channel in smooth muscle cells of the rat portal vein.

Authors: S Kajioka; M Oike; K Kitamura
Journal: J Pharmacol Exp Ther Date: 1990-09 Impact factor: 4.030

7. Effects of inositol phosphates on the membrane activity of smooth muscle cells of the rabbit portal vein.

Authors: Y Ohya; K Terada; K Yamaguchi; R Inoue; K Okabe; K Kitamura; M Hirata; H Kuriyama
Journal: Pflugers Arch Date: 1988-09 Impact factor: 3.657

8. Ryanodine inhibits the Ca-dependent K current after depletion of Ca stored in smooth muscle cells of the rabbit ileal longitudinal muscle.

Authors: T Sakai; K Terada; K Kitamura; H Kuriyama
Journal: Br J Pharmacol Date: 1988-12 Impact factor: 8.739

9. Cellular calcium regulates outward currents in rabbit intestinal smooth muscle cell.

Authors: Y Ohya; K Kitamura; H Kuriyama
Journal: Am J Physiol Date: 1987-04

9 in total

6 in total

1. Direct action of BRL 38227 and glibenclamide on intracellular calcium stores in cultured airway smooth muscle of rabbit.

Authors: L C Chopra; C H Twort; J P Ward
Journal: Br J Pharmacol Date: 1992-02 Impact factor: 8.739

2. Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta.

Authors: K Bray; U Quast
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-02 Impact factor: 3.000