Literature DB >> 190672

Serum myeloperoxidase and lactoferrin in neutropenia.

T Olofsson, I Olsson, P Venge, B Elgefors.   

Abstract

Radioimmunosorbent assays for determination of serum content of the neutrophil proteins myeloperoxidase and lactoferrin are described. Serial studies were performed in patients with neutropenia. In 2 cases of cyclic neutropenia the myeloperoxidase level showed slight variations within the normal range during the cycle while lactoferrin displayed a clear correlation with neutrophil counts. In 1 case with persistent agranulocytosis myeloperoxidase was normal but lactoferrin was extremely low. During the regeneration phase of drug-induced neutropenia neutrophil counts and serum lactoferrin increased in a parallel fashion. Since serum myeloperoxidase was normal during profounded neutropenia it is suggested to derive primarily from myeloperoxidase-rich granulopoietic precursor cells of the marrow. Serum lactoferrin on the other hand seems to derive from leakage of more granulopoietic cells of blood and marrow. Studies of neutrophil proteins of serum may aid in evaluation of neutropenic patients.

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Year:  1977        PMID: 190672     DOI: 10.1111/j.1600-0609.1977.tb01480.x

Source DB:  PubMed          Journal:  Scand J Haematol        ISSN: 0036-553X


  25 in total

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Authors:  R Hällgren; N Feltelius; R Garcia; P Venge; U Lindh
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5.  Human neutrophil lipocalin is a unique marker of neutrophil inflammation in ulcerative colitis and proctitis.

Authors:  M Carlson; Y Raab; L Sevéus; S Xu; R Hällgren; P Venge
Journal:  Gut       Date:  2002-04       Impact factor: 23.059

6.  Identification of a serum-derived promotor of granulocyte granule secretion: study on a patient with chronic pruritus.

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7.  Interleukin 1 administration in mice produces hypoferremia despite neutropenia.

Authors:  V R Gordeuk; P Prithviraj; T Dolinar; G M Brittenham
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Authors:  A Lundin; L Håkansson; R Hällgren; G Michaëlsson; P Venge
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9.  Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement.

Authors:  R Hällgren; A Bjelle; P Venge
Journal:  Ann Rheum Dis       Date:  1984-08       Impact factor: 19.103

10.  Self-labeling of human polymorphonuclear leucocyte myeloperoxidase with 125iodine.

Authors:  G Deby-Dupont; J Pincemail; A Thirion; C Deby; M Lamy; P Franchimont
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