Literature DB >> 19066780

Interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum in vitro.

Peter Starzengruber1, Herwig Kollaritsch, Jeeraphat Sirichaisinthop, Gunther Wernsdorfer, Kanungnit Congpuong, Walther H Wernsdorfer.   

Abstract

The pharmacodynamic interaction between lumefantrine and its monodesbutyl analogue (DBB) has been investigated in 35 fresh isolates of Plasmodium falciparum. Both compounds showed highly significant activity correlation. The geometric mean values for complete inhibition of schizont maturation (GMCOC) were 536,8 nM for lumefantrine, 246.0 nM for DBB, 235,5 nM for LUM-DBB 999:1, and 155,2 nM for LUM-DBB 995:5, with significant activity differences between lumefantrine and DBB as well as the LUM-DBB combinations. For the combination of lumefantrine and DBB 995:5 the sums of the fractional inhibitory concentrations according to Berenbaum (SFIC) indicated marked synergism, the intensity of interaction rising with the effective inhibitory concentrations.

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Year:  2008        PMID： 19066780     DOI： 10.1007/s00508-008-1080-8

Source DB:  PubMed          Journal:  Wien Klin Wochenschr        ISSN： 0043-5325            Impact factor:   1.704


  9 in total

1.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
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2.  Desbutyl-benflumetol, a novel antimalarial compound: in vitro activity in fresh isolates of Plasmodium falciparum from Thailand.

Authors:  H Noedl; T Allmendinger; S Prajakwong; G Wernsdorfer; W H Wernsdorfer
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

3.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

4.  Comparative study on the in vitro activity of lumefantrine and desbutyl-benflumetol in fresh isolates of Plasmodium vivax from Thailand.

Authors:  Daniela K Pirker-Krassnig; Gunther Wernsdorfer; Jeeraphat Sirichaisinthop; Chaiporn Rojanawatsirivet; Herwig Kollaritsch; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2004       Impact factor: 1.704

Review 5.  Malaria at the turn from the 2nd to the 3rd millenium.

Authors:  Gunther Wernsdorfer; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2003       Impact factor: 1.704

Review 6.  Coartemether (artemether and lumefantrine): an oral antimalarial drug.

Authors:  Walther H Wernsdorfer
Journal:  Expert Rev Anti Infect Ther       Date:  2004-04       Impact factor: 5.091

7.  Specific pharmacokinetic interaction between lumefantrine and monodesbutyl-benflumetol in Plasmodium falciparum.

Authors:  Peter Starzengruber; Gunther Wernsdorfer; Maria Parizek; Chaiporn Rojanawatsirivet; Herwig Kollaritsch; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2007       Impact factor: 1.704

Review 8.  Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.

Authors:  Shunmay Yeung; Wirichada Pongtavornpinyo; Ian M Hastings; Anne J Mills; Nicholas J White
Journal:  Am J Trop Med Hyg       Date:  2004-08       Impact factor: 2.345

9.  Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

Authors:  Martin Traebert; Bérengère Dumotier; Lothar Meister; Peter Hoffmann; Manuel Dominguez-Estevez; Willi Suter
Journal:  Eur J Pharmacol       Date:  2004-01-19       Impact factor: 4.432
  9 in total
  3 in total

1.  Pharmacodynamic interaction between lumefantrine and desbutyl-benflumetol in Plasmodium falciparum in vitro.

Authors:  Alexander Leeb; Gunther Wernsdorfer; Wichai Satimai; Ursula Wiedermann; Kanungnit Congpuong; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2010-10       Impact factor: 1.704

2.  Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria.

Authors:  Sam Salman; Madhu Page-Sharp; Susan Griffin; Kaye Kose; Peter M Siba; Kenneth F Ilett; Ivo Mueller; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2011-08-29       Impact factor: 5.191

3.  Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome.

Authors:  Rina P M Wong; Sam Salman; Kenneth F Ilett; Peter M Siba; Ivo Mueller; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2011-01-03       Impact factor: 5.191
  3 in total

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