| Literature DB >> 19066426 |
H Kumagami1, M Terakado, Y Sainoo, A Baba, D Fujiyama, T Fukuda, K Takasaki, H Takahashi.
Abstract
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac. Copyright 2008 S. Karger AG, Basel.Entities:
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Year: 2008 PMID： 19066426 DOI： 10.1159/000180290
Source DB: PubMed Journal: Audiol Neurootol ISSN： 1420-3030 Impact factor: 1.854