Literature DB >> 19066214

Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.

Tie-Jun Sten Shi1, Su-Xing Leslie Liu, Henrik Hammarberg, Masahiko Watanabe, Zhi-Qing David Xu, Tomas Hökfelt.   

Abstract

Treatment of neuropathic pain is a major clinical problem. This study shows expression of phospholipase ss3 (PLCss3) in mouse and human DRG neurons, mainly in small ones and mostly with a nonpeptidergic phenotype. After spared nerve injury, the pain threshold was strongly reduced, and systemic treatment of such animals with the unselective PLC inhibitor U73122 caused a rapid and long-lasting (48-h) increase in pain threshold. Thus, inhibition of PLC may provide a way to treat neuropathic pain.

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Year:  2008        PMID： 19066214      PMCID： PMC2604939          DOI： 10.1073/pnas.0810899105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

Authors:  H H Chuang ; E D Prescott; H Kong; S Shields; S E Jordt; A I Basbaum; M V Chao; D Julius
Journal:  Nature       Date:  2001-06-21       Impact factor: 49.962

Review 2.  Regulation of phosphoinositide-specific phospholipase C.

Authors:  S G Rhee
Journal:  Annu Rev Biochem       Date:  2001       Impact factor: 23.643

3.  Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.

Authors:  H X Liu; P Brumovsky; R Schmidt; W Brown; K Payza; L Hodzic; C Pou; C Godbout; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

4.  Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury.

Authors:  H Tsujino; E Kondo; T Fukuoka; Y Dai; A Tokunaga; K Miki; K Yonenobu; T Ochi; K Noguchi
Journal:  Mol Cell Neurosci       Date:  2000-02       Impact factor: 4.314

5.  Spared nerve injury: an animal model of persistent peripheral neuropathic pain.

Authors:  Isabelle Decosterd; Clifford J Woolf
Journal:  Pain       Date:  2000-08       Impact factor: 6.961

6.  Excitatory effects of galanin in the spinal cord of intact, anaesthetized rats.

Authors:  A J Reeve; K Walker; L Urban; A Fox
Journal:  Neurosci Lett       Date:  2000-12-01       Impact factor: 3.046

Review 7.  The participation of galanin in pain processing at the spinal level.

Authors:  Hong-Xiang Liu; Tomas Hökfelt
Journal:  Trends Pharmacol Sci       Date:  2002-10       Impact factor: 14.819

Review 8.  Management of neuropathic pain.

Authors:  Troels S Jensen; Nanna Brix Finnerup
Journal:  Curr Opin Support Palliat Care       Date:  2007-08       Impact factor: 2.302

9.  Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain.

Authors:  Mariko Miyata; Hideki Kashiwadani; Masahiro Fukaya; Takayuki Hayashi; Dianqing Wu; Tutomu Suzuki; Masahiko Watanabe; Yoriko Kawakami
Journal:  J Neurosci       Date:  2003-09-03       Impact factor: 6.167

10.  Galanin expression in adult human dorsal root ganglion neurons: initial observations.

Authors:  M Landry; K Aman; J Dostrovsky; A M Lozano; T Carlstedt; C Spenger; A Josephson; Z Wiesenfeld-Hallin; T Hökfelt
Journal:  Neuroscience       Date:  2003       Impact factor: 3.590
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  23 in total

1.  Shared mechanisms for opioid tolerance and a transition to chronic pain.

Authors:  Elizabeth K Joseph; David B Reichling; Jon D Levine
Journal:  J Neurosci       Date:  2010-03-31       Impact factor: 6.167

2.  In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.

Authors:  Eitaro Aihara; Courtney L Hentz; Abraham M Korman; Nicholas P J Perry; Vikram Prasad; Gary E Shull; Marshall H Montrose
Journal:  J Biol Chem       Date:  2013-10-11       Impact factor: 5.157

3.  Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Authors:  Ming-Dong Zhang; Swapnali Barde; Ting Yang; Beilei Lei; Lars I Eriksson; Joseph P Mathew; Thomas Andreska; Katerina Akassoglou; Tibor Harkany; Tomas G M Hökfelt; Niccolò Terrando
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

4.  Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

Authors:  Xiaoyang Wang; Matthew Barrett; John Sondek; T Kendall Harden; Qisheng Zhang
Journal:  Biochemistry       Date:  2012-06-22       Impact factor: 3.162

5.  The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.

Authors:  Z Li; S-Q He; P-Y Tseng; Q Xu; V Tiwari; F Yang; B Shu; T Zhang; Z Tang; S N Raja; Y Wang; X Dong; Y Guan
Journal:  Neuroscience       Date:  2015-05-27       Impact factor: 3.590

6.  Required hydrophobicity of fluorescent reporters for phosphatidylinositol family of lipid enzymes.

Authors:  Jarod Waybright; Weigang Huang; Angela Proctor; Xiaoyang Wang; Nancy L Allbritton; Qisheng Zhang
Journal:  Anal Bioanal Chem       Date:  2017-09-20       Impact factor: 4.142

7.  A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes.

Authors:  Weigang Huang; Stephanie N Hicks; John Sondek; Qisheng Zhang
Journal:  ACS Chem Biol       Date:  2011-01-10       Impact factor: 5.100

8.  Inward-rectifying K+ (Kir2) leak conductance dampens the excitability of lamina I projection neurons in the neonatal rat.

Authors:  Neil C Ford; Mark L Baccei
Journal:  Neuroscience       Date:  2016-10-14       Impact factor: 3.590

Review 9.  Neural processing of itch.

Authors:  Tasuku Akiyama; E Carstens
Journal:  Neuroscience       Date:  2013-07-24       Impact factor: 3.590

10.  Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model.

Authors:  Tie-Jun Sten Shi; Ming-Dong Zhang; Hugo Zeberg; Johanna Nilsson; Jacob Grünler; Su-Xing Liu; Qiong Xiang; Jonas Persson; Kaj J Fried; Sergiu Bogdan Catrina; Masahiko Watanabe; Peter Arhem; Kerstin Brismar; Tomas G M Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-24       Impact factor: 11.205
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