Literature DB >> 19065000

Lysophospholipid receptors in vertebrate development, physiology, and pathology.

Athanasia Skoura1, Timothy Hla.   

Abstract

Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune cell trafficking and inflammatory reactions. LP signaling is important in cancer, autoimmunity and inflammatory diseases. Research on LP biology has contributed to the development of a first-generation S1P receptor modulator that has entered phase III clinical trials for the treatment of multiple sclerosis. Further basic research on LP signaling is anticipated to lead to novel therapeutic tools to combat various human diseases.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19065000      PMCID： PMC2674736          DOI： 10.1194/jlr.R800047-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  58 in total

1.  Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

Authors:  Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth Quackenbush; Jenny Xie; James Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; CarolAnn Keohane; Mark Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen Rupprecht; William Parsons; Hugh Rosen
Journal:  Science       Date:  2002-03-28       Impact factor: 47.728

2.  The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

Authors:  Volker Brinkmann; Michael D Davis; Christopher E Heise; Rainer Albert; Sylvain Cottens; Robert Hof; Christian Bruns; Eva Prieschl; Thomas Baumruker; Peter Hiestand; Carolyn A Foster; Markus Zollinger; Kevin R Lynch
Journal:  J Biol Chem       Date:  2002-04-19       Impact factor: 5.157

3.  Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.

Authors:  Y Morita; G I Perez; F Paris; S R Miranda; D Ehleiter; A Haimovitz-Friedman; Z Fuks; Z Xie; J C Reed; E H Schuchman; R N Kolesnick; J L Tilly
Journal:  Nat Med       Date:  2000-10       Impact factor: 53.440

4.  Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

Authors:  M J Lee; J R Van Brocklyn; S Thangada; C H Liu; A R Hand; R Menzeleev; S Spiegel; T Hla
Journal:  Science       Date:  1998-03-06       Impact factor: 47.728

5.  Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.

Authors:  I Y Dobrosotskaya; A C Seegmiller; M S Brown; J L Goldstein; R B Rawson
Journal:  Science       Date:  2002-05-03       Impact factor: 47.728

6.  Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.

Authors:  M J Lee; S Thangada; K P Claffey; N Ancellin; C H Liu; M Kluk; M Volpi; R I Sha'afi; T Hla
Journal:  Cell       Date:  1999-10-29       Impact factor: 41.582

7.  Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

Authors:  Y Liu; R Wada; T Yamashita; Y Mi; C X Deng; J P Hobson; H M Rosenfeldt; V E Nava; S S Chae; M J Lee; C H Liu; T Hla; S Spiegel; R L Proia
Journal:  J Clin Invest       Date:  2000-10       Impact factor: 14.808

Review 8.  Sphingosine-1-phosphate: an enigmatic signalling lipid.

Authors:  Sarah Spiegel; Sheldon Milstien
Journal:  Nat Rev Mol Cell Biol       Date:  2003-05       Impact factor: 94.444

9.  Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques.

Authors:  Enno Rother; Richard Brandl; Daniel L Baker; Pankaj Goyal; Harry Gebhard; Gabor Tigyi; Wolfgang Siess
Journal:  Circulation       Date:  2003-07-28       Impact factor: 29.690

Review 10.  The emerging role of lysophosphatidic acid in cancer.

Authors:  Gordon B Mills; Wouter H Moolenaar
Journal:  Nat Rev Cancer       Date:  2003-08       Impact factor: 60.716
View more
  37 in total

Review 1.  Truth and consequences of sphingosine-1-phosphate lyase.

Authors:  Ana Aguilar; Julie D Saba
Journal:  Adv Biol Regul       Date:  2012-01

Review 2.  International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.

Authors:  Jerold Chun; Timothy Hla; Kevin R Lynch; Sarah Spiegel; Wouter H Moolenaar
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 3.  Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.

Authors:  Dong-Soon Im
Journal:  Acta Pharmacol Sin       Date:  2010-08-23       Impact factor: 6.150

Review 4.  Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Authors:  Volker Brinkmann; Andreas Billich; Thomas Baumruker; Peter Heining; Robert Schmouder; Gordon Francis; Shreeram Aradhye; Pascale Burtin
Journal:  Nat Rev Drug Discov       Date:  2010-10-29       Impact factor: 84.694

5.  Serotonergic neuron regulation informed by in vivo single-cell transcriptomics.

Authors:  Jennifer M Spaethling; David Piel; Hannah Dueck; Peter T Buckley; Jacqueline F Morris; Stephen A Fisher; Jaehee Lee; Jai-Yoon Sul; Junhyong Kim; Tamas Bartfai; Sheryl G Beck; James H Eberwine
Journal:  FASEB J       Date:  2013-11-05       Impact factor: 5.191

Review 6.  Extracellular matrix, inflammation, and the angiogenic response.

Authors:  Alicia G Arroyo; M Luisa Iruela-Arispe
Journal:  Cardiovasc Res       Date:  2010-02-12       Impact factor: 10.787

7.  Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.

Authors:  Jason Emo; Nida Meednu; Timothy J Chapman; Fariba Rezaee; Marlene Balys; Troy Randall; Tirumalai Rangasamy; Steve N Georas
Journal:  J Immunol       Date:  2012-03-16       Impact factor: 5.422

8.  The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.

Authors:  Gwynneth Thomas; Jenna L Betters; Caleb C Lord; Amanda L Brown; Stephanie Marshall; Daniel Ferguson; Janet Sawyer; Matthew A Davis; John T Melchior; Lawrence C Blume; Allyn C Howlett; Pavlina T Ivanova; Stephen B Milne; David S Myers; Irina Mrak; Vera Leber; Christoph Heier; Ulrike Taschler; Jacqueline L Blankman; Benjamin F Cravatt; Richard G Lee; Rosanne M Crooke; Mark J Graham; Robert Zimmermann; H Alex Brown; J Mark Brown
Journal:  Cell Rep       Date:  2013-10-03       Impact factor: 9.423

9.  Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.

Authors:  Khalil J Diab; Jeremy J Adamowicz; Krzysztof Kamocki; Natalia I Rush; Jana Garrison; Yuan Gu; Kelly S Schweitzer; Anastasia Skobeleva; Gangaraju Rajashekhar; Walter C Hubbard; Evgeny V Berdyshev; Irina Petrache
Journal:  Am J Respir Crit Care Med       Date:  2009-12-03       Impact factor: 21.405

Review 10.  Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.

Authors:  Xiaoqin Ye; Jerold Chun
Journal:  Trends Endocrinol Metab       Date:  2010-01       Impact factor: 12.015
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.