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Literature DB >> 19064802

Multimodal neuroprotective therapy with induced hypothermia after ischemic stroke.

Abstract

Neuroprotective therapies have so far failed to provide improved neurological function and outcome after stroke. A recent focus on multimodal therapies, including the combination of neuroprotective medications with hypothermia, opens a promising new treatment strategy. Advances in hypothermia administration make it one of the most promising neuroprotective therapies available and an ideal candidate for combination with other neuroprotective approaches.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 19064802 PMCID： PMC2692244 DOI： 10.1161/STROKEAHA.108.533083

Source DB: PubMed Journal: Stroke ISSN： 0039-2499 Impact factor: 7.914

43 in total

Review 1. Recommendations for clinical trial evaluation of acute stroke therapies.

Authors:
Journal: Stroke Date: 2001-07 Impact factor: 7.914

2. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association.

Authors: Harold Adams; Robert Adams; Gregory Del Zoppo; Larry B Goldstein
Journal: Stroke Date: 2005-04 Impact factor: 7.914

3. Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial.

Authors: Kennedy R Lees; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; James Grotta; Patrick Lyden; Ashfaq Shuaib; Tim Ashwood; Hans-Goran Hardemark; Warren Wasiewski; Ugochi Emeribe; Justin A Zivin
Journal: Stroke Date: 2006-10-26 Impact factor: 7.914

4. Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model.

Authors: M Andersen; K Overgaard; P Meden; G Boysen; S C Choi
Journal: Stroke Date: 1999-07 Impact factor: 7.914

5. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.

Authors: M Asahi; X Wang; T Mori; T Sumii; J C Jung; M A Moskowitz; M E Fini; E H Lo
Journal: J Neurosci Date: 2001-10-01 Impact factor: 6.167

6. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia.

Authors: R Popovic; R Liniger; P E Bickler
Journal: Anesthesiology Date: 2000-05 Impact factor: 7.892

7. Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.

Authors: D W Krieger; M A De Georgia; A Abou-Chebl; J C Andrefsky; C A Sila; I L Katzan; M R Mayberg; A J Furlan
Journal: Stroke Date: 2001-08 Impact factor: 7.914

8. NXY-059 for acute ischemic stroke.

Authors: Kennedy R Lees; Justin A Zivin; Tim Ashwood; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; James Grotta; Patrick Lyden; Ashfaq Shuaib; Hans-Göran Hårdemark; Warren W Wasiewski
Journal: N Engl J Med Date: 2006-02-09 Impact factor: 91.245

9. NXY-059 for the treatment of acute ischemic stroke.

Authors: Ashfaq Shuaib; Kennedy R Lees; Patrick Lyden; James Grotta; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; Tim Ashwood; Warren W Wasiewski; Ugochi Emeribe
Journal: N Engl J Med Date: 2007-08-09 Impact factor: 91.245

10. PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480].

Authors: Eric J van Breda; H Bart van der Worp; H Maarten A van Gemert; Ale Algra; L Jaap Kappelle; Jan van Gijn; Peter J Koudstaal; Diederik W J Dippel
Journal: BMC Cardiovasc Disord Date: 2005-08-19 Impact factor: 2.298

5 in total

Multimodal neuroprotective therapy with induced hypothermia after ischemic stroke.

Review 1. Recommendations for clinical trial evaluation of acute stroke therapies.

2. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association.

3. Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial.

4. Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model.

5. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia.

6. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia.

7. Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke.

8. NXY-059 for acute ischemic stroke.

9. NXY-059 for the treatment of acute ischemic stroke.

10. PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial [ISCRTN 74418480].

1. Incrementally applied multifaceted therapeutic bundles in neuroprotection clinical trials...time for change.

2. Induction of a prolonged hypothermic state by drug-induced reduction in the thermoregulatory set-point.

3. Therapeutic hypothermia for acute air embolic stroke.

4. Combination of therapeutic hypothermia and other neuroprotective strategies after an ischemic cerebral insult.

5. Extended Use of Hypothermia in Elderly Patients with Malignant Cerebral Edema as an Alternative to Hemicraniectomy.