Literature DB >> 19064713

HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.

Sonia Schott1, Fabien Ramos, Vincent Coustham, Francesca Palladino.   

Abstract

A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.

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Year:  2008        PMID： 19064713      PMCID： PMC2644966          DOI： 10.1534/genetics.108.089276

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  28 in total

1.  Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes.

Authors:  Michael Korenjak; Barbie Taylor-Harding; Ulrich K Binné; John S Satterlee; Olivier Stevaux; Rein Aasland; Helen White-Cooper; Nick Dyson; Alexander Brehm
Journal:  Cell       Date:  2004-10-15       Impact factor: 41.582

2.  Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.

Authors:  Peter W Lewis; Eileen L Beall; Tracey C Fleischer; Daphne Georlette; Andrew J Link; Michael R Botchan
Journal:  Genes Dev       Date:  2004-11-15       Impact factor: 11.361

3.  Transcriptional upregulation of the C. elegans Hox gene lin-39 during vulval cell fate specification.

Authors:  Javier A Wagmaister; Julie E Gleason; David M Eisenmann
Journal:  Mech Dev       Date:  2006-01-18       Impact factor: 1.882

Review 4.  Vulval development in Caenorhabditis elegans.

Authors:  K Kornfeld
Journal:  Trends Genet       Date:  1997-02       Impact factor: 11.639

5.  The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

Authors:  E L Ferguson; H R Horvitz
Journal:  Genetics       Date:  1989-09       Impact factor: 4.562

6.  The ncl-1 gene and genetic mosaics of Caenorhabditis elegans.

Authors:  E M Hedgecock; R K Herman
Journal:  Genetics       Date:  1995-11       Impact factor: 4.562

7.  lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans.

Authors:  Toshia R Myers; Iva Greenwald
Journal:  Dev Cell       Date:  2005-01       Impact factor: 12.270

8.  lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

Authors:  X Lu; H R Horvitz
Journal:  Cell       Date:  1998-12-23       Impact factor: 41.582

9.  The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.

Authors:  J H Thomas; H R Horvitz
Journal:  Development       Date:  1999-08       Impact factor: 6.868

10.  EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.

Authors:  Amit Dutt; Stefano Canevascini; Erika Froehli-Hoier; Alex Hajnal
Journal:  PLoS Biol       Date:  2004-09-28       Impact factor: 8.029
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  5 in total

1.  Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.

Authors:  Maja Studencka; Radosław Wesołowski; Lennart Opitz; Gabriela Salinas-Riester; Jacek R Wisniewski; Monika Jedrusik-Bode
Journal:  PLoS Genet       Date:  2012-09-13       Impact factor: 5.917

2.  The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF.

Authors:  Adam M Saffer; Dong Hyun Kim; Alexander van Oudenaarden; H Robert Horvitz
Journal:  PLoS Genet       Date:  2011-12-29       Impact factor: 5.917

3.  Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.

Authors:  Peter Meister; Sonia Schott; Cécile Bedet; Yu Xiao; Sabine Rohner; Selena Bodennec; Bruno Hudry; Laurent Molin; Florence Solari; Susan M Gasser; Francesca Palladino
Journal:  Genome Biol       Date:  2011-12-20       Impact factor: 13.583

4.  Histone H1 and heterochromatin protein 1 (HP1) regulate specific gene expression and not global transcription.

Authors:  Monika Jedrusik-Bode
Journal:  Worm       Date:  2013-04-01

Review 5.  Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function.

Authors:  Julie Ahringer; Susan M Gasser
Journal:  Genetics       Date:  2018-02       Impact factor: 4.562
  5 in total

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