| Literature DB >> 19064320 |
Michal Novotný1, Alexandr Hrabálek, Barbora Janůsová, Jakub Novotný, Katerina Vávrová.
Abstract
A series of transdermal permeation enhancers based on dicarboxylic acid esters was studied. Single-chain amphiphiles were markedly more effective than the double-chain ones. Monododecyl maleate, that is a cis derivative, was a more potent enhancer than its trans isomer, while the activity of succinates strongly depended on the donor vehicle. No difference between diastereoisomeric tartaric and meso-tartaric acid derivatives was found.Entities:
Mesh：
Substances：
Year: 2008 PMID： 19064320 DOI： 10.1016/j.bmcl.2008.11.083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823