Literature DB >> 19064250

Malaria pulls a FASt one.

Maroya D Spalding1, Sean T Prigge.   

Abstract

Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development.

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Year:  2008        PMID： 19064250     DOI： 10.1016/j.chom.2008.11.006

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  6 in total

1.  The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

Authors:  Craig Wilkinson; Martin J McPhillie; Ying Zhou; Stuart Woods; Gustavo A Afanador; Shaun Rawson; Farzana Khaliq; Sean T Prigge; Craig W Roberts; David W Rice; Rima McLeod; Colin W Fishwick; Stephen P Muench
Journal:  Bioorg Med Chem Lett       Date:  2013-12-22       Impact factor: 2.823

2.  Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.

Authors:  Choukri Ben Mamoun; Sean T Prigge; Henri Vial
Journal:  Drug Dev Res       Date:  2010-02       Impact factor: 4.360

3.  Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Authors:  Carola Huthmacher; Andreas Hoppe; Sascha Bulik; Hermann-Georg Holzhütter
Journal:  BMC Syst Biol       Date:  2010-08-31

4.  Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents.

Authors:  Florian C Schrader; Serghei Glinca; Julia M Sattler; Hans-Martin Dahse; Gustavo A Afanador; Sean T Prigge; Michael Lanzer; Ann-Kristin Mueller; Gerhard Klebe; Martin Schlitzer
Journal:  ChemMedChem       Date:  2013-01-22       Impact factor: 3.466

5.  Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.

Authors:  Lorillee C Tallorin; Jacob D Durrant; Quynh G Nguyen; J Andrew McCammon; Michael D Burkart
Journal:  Bioorg Med Chem       Date:  2014-09-15       Impact factor: 3.641

6.  Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

Authors:  Stephen P Muench; Jozef Stec; Ying Zhou; Gustavo A Afanador; Martin J McPhillie; Mark R Hickman; Patty J Lee; Susan E Leed; Jennifer M Auschwitz; Sean T Prigge; David W Rice; Rima McLeod
Journal:  Bioorg Med Chem Lett       Date:  2013-04-24       Impact factor: 2.823
  6 in total

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