BACKGROUND: cAMP is a second messenger that plays a role in intracellular signal transduction of various stimuli. a major function of cAMP in eukaryotes is activation of cAMP-dependent protein kinase (PKA). PKA is the best understood member of the serine-threonine protein kinase superfamily, and is involved in the control of a variety of cellular processes. since it has been implicated in the initiation and progression of many tumors, PKA has been suggested as a novel molecular target for cancer therapy. OBJECTIVE/ METHODS: Here, after describing some features of cAMP/PKA signaling that are relevant to cancer biology, we review targeting of PKA in cancer therapy, also discussing PKA as a biomarker for cancer detection and monitoring of therapy. RESULTS/ CONCLUSIONS: PKA is an increasingly relevant biological target in the therapy and management of cancer.
BACKGROUND:cAMP is a second messenger that plays a role in intracellular signal transduction of various stimuli. a major function of cAMP in eukaryotes is activation of cAMP-dependent protein kinase (PKA). PKA is the best understood member of the serine-threonine protein kinase superfamily, and is involved in the control of a variety of cellular processes. since it has been implicated in the initiation and progression of many tumors, PKA has been suggested as a novel molecular target for cancer therapy. OBJECTIVE/ METHODS: Here, after describing some features of cAMP/PKA signaling that are relevant to cancer biology, we review targeting of PKA in cancer therapy, also discussing PKA as a biomarker for cancer detection and monitoring of therapy. RESULTS/ CONCLUSIONS: PKA is an increasingly relevant biological target in the therapy and management of cancer.
Authors: T Ihara; Y Hosokawa; K Kumazawa; K Ishikawa; J Fujimoto; M Yamamoto; T Muramkami; N Goshima; E Ito; S Watanabe; K Semba Journal: Oncogene Date: 2016-10-03 Impact factor: 9.867
Authors: Shuai Yu; He Huang; Anton Iliuk; Wen-Horng Wang; Keerthi B Jayasundera; W Andy Tao; Carol B Post; Robert L Geahlen Journal: J Biol Chem Date: 2013-02-27 Impact factor: 5.157
Authors: Linah F Al-Alem; Lauren A McCord; R Chase Southard; Michael W Kilgore; Thomas E Curry Journal: Biol Reprod Date: 2013-09-27 Impact factor: 4.285