Literature DB >> 1906280

Regulation of the immune response in lymphatic filariasis and onchocerciasis.

C L King1, T B Nutman.   

Abstract

The persistence of microfilariae in the blood or skin accompanied by a prominent eosinophilia and elevated serum IgE levels are common features of human infection with filarial parasites. In this review Christopher King and Thomas Nutman discuss recent findings on the role of interleukin 4 (IL-4), IL-5 and gamma-interferon (IFN-gamma) in the induction of these immediate hypersensitivity responses. They discuss the role of hypersensitivity in immunity, the development of immune tolerance to filarial antigens and suggest that could explain the impaired immune response of some individuals to filarial infections and the persistence of the microfilaremic state.

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Year:  1991        PMID： 1906280     DOI： 10.1016/S0167-5699(05)80016-7

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  36 in total

1.  Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.

Authors:  S K Dalai; D Das; S K Kar
Journal:  J Clin Immunol       Date:  1998-03       Impact factor: 8.317

2.  Protective responses against skin-dwelling microfilariae of Onchocerca lienalis in severe combined immunodeficient mice.

Authors:  S G Folkard; M J Taylor; G A Butcher; A E Bianco
Journal:  Infect Immun       Date:  1997-07       Impact factor: 3.441

Review 3.  Immunopathogenesis of lymphatic filarial disease.

Authors:  Subash Babu; Thomas B Nutman
Journal:  Semin Immunopathol       Date:  2012-10-03       Impact factor: 9.623

4.  Human onchocerciasis and tetanus vaccination: impact on the postvaccination antitetanus antibody response.

Authors:  P J Cooper; I Espinel; M Wieseman; W Paredes; M Espinel; R H Guderian; T B Nutman
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

5.  Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi.

Authors:  J E Allen; R A Lawrence; R M Maizels
Journal:  Infect Immun       Date:  1995-08       Impact factor: 3.441

6.  Regulatory effects of Th1-type (IFN-gamma, IL-12) and Th2-type cytokines (IL-10, IL-13) on parasite-specific cellular responsiveness in Onchocerca volvulus-infected humans and exposed endemic controls.

Authors:  P T Soboslay; C G Lüder; S Riesch; S M Geiger; M Banla; E Batchassi; A Stadler; H Schulz-Key
Journal:  Immunology       Date:  1999-06       Impact factor: 7.397

7.  Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology.

Authors:  Subash Babu; R Anuradha; N Pavan Kumar; P Jovvian George; V Kumaraswami; Thomas B Nutman
Journal:  Infect Immun       Date:  2012-04-16       Impact factor: 3.441

8.  Transcriptional control of impaired Th1 responses in patent lymphatic filariasis by T-box expressed in T cells and suppressor of cytokine signaling genes.

Authors:  Subash Babu; V Kumaraswami; Thomas B Nutman
Journal:  Infect Immun       Date:  2005-06       Impact factor: 3.441

9.  Immunoprophylaxis of multi-antigen peptide (MAP) vaccine for human lymphatic filariasis.

Authors:  Christiana Immanuel; Aparnaa Ramanathan; Malathi Balasubramaniyan; Vishal Kishor Khatri; Nitin Purushottam Amdare; Donthamsetty Nageswara Rao; Maryada Venkata Rami Reddy; Kaliraj Perumal
Journal:  Immunol Res       Date:  2017-06       Impact factor: 2.829

10.  Impairment of tetanus-specific cellular and humoral responses following tetanus vaccination in human lymphatic filariasis.

Authors:  Suba Nookala; Sundaram Srinivasan; Perumal Kaliraj; Rangarajan Badri Narayanan; Thomas B Nutman
Journal:  Infect Immun       Date:  2004-05       Impact factor: 3.441
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