Literature DB >> 19062275

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.

Victor J Cee1, Alan C Cheng, Karina Romero, Steve Bellon, Christopher Mohr, Douglas A Whittington, Annette Bak, James Bready, Sean Caenepeel, Angela Coxon, Holly L Deak, Jenne Fretland, Yan Gu, Brian L Hodous, Xin Huang, Joseph L Kim, Jasmine Lin, Alexander M Long, Hanh Nguyen, Philip R Olivieri, Vinod F Patel, Ling Wang, Yihong Zhou, Paul Hughes, Stephanie Geuns-Meyer.   

Abstract

Selective small molecule inhibitors of Tie-2 kinase are important tools for the validation of Tie-2 signaling in pathological angiogenesis. Reported herein is the optimization of a nonselective scaffold into a potent and highly selective inhibitor of Tie-2 kinase.

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Year:  2008        PMID： 19062275     DOI： 10.1016/j.bmcl.2008.11.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.

Authors:  Paul E Harrington; Kaustav Biswas; David Malwitz; Andrew S Tasker; Christopher Mohr; Kristin L Andrews; Ken Dellamaggiore; Richard Kendall; Holger Beckmann; Peter Jaeckel; Silvia Materna-Reichelt; Jennifer R Allen; J Russell Lipford
Journal:  ACS Med Chem Lett       Date:  2014-09-24       Impact factor: 4.345

2.  Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors.

Authors:  Silvia Salerno; Elisabetta Barresi; Aída Nelly García-Argáez; Sabrina Taliani; Francesca Simorini; Giorgio Amendola; Stefano Tomassi; Sandro Cosconati; Ettore Novellino; Federico Da Settimo; Anna Maria Marini; Lisa Dalla Via
Journal:  ACS Med Chem Lett       Date:  2019-01-17       Impact factor: 4.345

3.  A zebrafish in vivo phenotypic assay to identify 3-aminothiophene-2-carboxylic acid-based angiogenesis inhibitors.

Authors:  Athanasios Papakyriakou; Panagiotis Kefalos; Panagiotis Sarantis; Christos Tsiamantas; Kleanthis P Xanthopoulos; Dionisios Vourloumis; Dimitris Beis
Journal:  Assay Drug Dev Technol       Date:  2014 Nov-Dec       Impact factor: 1.738

4.  Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles.

Authors:  Satoshi Ueda; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-11       Impact factor: 15.336

5.  Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach.

Authors:  Kingkan Sanphanya; Suvara K Wattanapitayakul; Suwadee Phowichit; Valery V Fokin; Opa Vajragupta
Journal:  Bioorg Med Chem Lett       Date:  2013-03-20       Impact factor: 2.823

6.  Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase.

Authors:  Kornelia Czaja; Jacek Kujawski; Paweł Śliwa; Rafał Kurczab; Radosław Kujawski; Anna Stodolna; Agnieszka Myślińska; Marek K Bernard
Journal:  Int J Mol Sci       Date:  2020-07-07       Impact factor: 5.923
  6 in total

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