OBJECTIVES: To evaluate the recurrence rates of cervical intraepithelial neoplasia (CIN) in a cohort of HIV-infected and noninfected women who underwent the loop electrosurgical excision procedure (LEEP). METHODS: A prospective cohort study of 94 HIV-positive and 107 HIV-negative women, both with CIN, treated with LEEP. The diagnosis of recurrence was established after biopsy. The Kaplan-Meier method was used for survival analysis and multivariate analyses were carried out using the Cox proportional hazards regression model. RESULTS: There was a predominance of low-grade lesions in HIV-positive compared with HIV-negative women (P<0.01). Recurrence was more frequent with compromised margins and glandular involvement (P<0.01). A multivariate analysis showed that HIV-infection, glandular involvement, and positive margins were independently associated with recurrence of lesions. CONCLUSIONS: Recurrence rate of CIN in HIV-positive women was higher than in HIV-negative women. The factors associated with recurrence were HIV infection, glandular involvement, and positive margins.
OBJECTIVES: To evaluate the recurrence rates of cervical intraepithelial neoplasia (CIN) in a cohort of HIV-infected and noninfected women who underwent the loop electrosurgical excision procedure (LEEP). METHODS: A prospective cohort study of 94 HIV-positive and 107 HIV-negative women, both with CIN, treated with LEEP. The diagnosis of recurrence was established after biopsy. The Kaplan-Meier method was used for survival analysis and multivariate analyses were carried out using the Cox proportional hazards regression model. RESULTS: There was a predominance of low-grade lesions in HIV-positive compared with HIV-negative women (P<0.01). Recurrence was more frequent with compromised margins and glandular involvement (P<0.01). A multivariate analysis showed that HIV-infection, glandular involvement, and positive margins were independently associated with recurrence of lesions. CONCLUSIONS: Recurrence rate of CIN in HIV-positive women was higher than in HIV-negative women. The factors associated with recurrence were HIV infection, glandular involvement, and positive margins.
Authors: Laura L Reimers; Susan Sotardi; David Daniel; Lydia G Chiu; Anne Van Arsdale; Daryl L Wieland; Jason M Leider; Xiaonan Xue; Howard D Strickler; David J Garry; Gary L Goldberg; Mark H Einstein Journal: Gynecol Oncol Date: 2010-10 Impact factor: 5.482
Authors: Aristoteles Mauricio Garcia Ramos; Erika Souza Garcia Ramos; Helena Lucia Barroso Dos Reis; Ricardo Bueno de Rezende Journal: J Clin Med Res Date: 2015-02-09
Authors: Emmanuel A Oga; Jessica P Brown; Clayton Brown; Eileen Dareng; Victor Adekanmbi; Michael Odutola; Olayinka Olaniyan; Richard Offiong; Kayode Obende; Ayodele Stephen Adewole; Achara Peter; Patrick Dakum; Clement Adebamowo Journal: BMC Womens Health Date: 2016-05-11 Impact factor: 2.809
Authors: Phuong Lien Tran; Bruno Kenfack; Eveline Tincho Foguem; Manuela Viviano; Liliane Temogne; Pierre-Marie Tebeu; Rosa Catarino; Anne-Caroline Benski; Pierre Vassilakos; Patrick Petignat Journal: Int J Womens Health Date: 2017-12-01