Satin S Patel1, Kelley S Carrick, Bruce R Carr. 1. Departments of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.
Abstract
OBJECTIVE: To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. DESIGN: Case report. SETTING: University medical center. PATIENT(S): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. INTERVENTION(S): Exploratory laparotomy with full staging. MAIN OUTCOME MEASURE(S): Surgical findings and histopathologic observations are included in this report. RESULT(S): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. CONCLUSION(S): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.
OBJECTIVE: To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. DESIGN: Case report. SETTING: University medical center. PATIENT(S): A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. INTERVENTION(S): Exploratory laparotomy with full staging. MAIN OUTCOME MEASURE(S): Surgical findings and histopathologic observations are included in this report. RESULT(S): Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. CONCLUSION(S): Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.