J C Trussell1, Allen R Kunselman, Richard S Legro. 1. Division of Urology, Penn State Milton S. Hershey Medical Center, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA. jtrussell@psu.edu
Abstract
OBJECTIVE: To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls. DESIGN: Prospective case-control study. SETTING: Academic medical center. PATIENT(S): Twenty-nine nondiabetic men aged 18-66 years were enrolled. Of these, 28 completed the study: 17 had ED, and 11 did not. INTERVENTION(S): Validated ED questionnaires, examination, serum hormones evaluation, and oral glucose tolerance testing. MAIN OUTCOME MEASURE(S): Association of IR with ED. RESULT(S): The association between worsening degrees of both lower urinary tract symptoms (LUTS) and ED was reaffirmed, as was a potential correlation between the two-epinephrine. There was a negative association between serum levels of epinephrine and scores on the 5-item version of the International Index of Erectile Dysfunction for ED (Spearman correlation coefficient = -0.38). On the other hand, men with ED were not more likely to have IR compared with controls. CONCLUSION(S): Epinephrine may be the common link between ED and LUTS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls. DESIGN: Prospective case-control study. SETTING: Academic medical center. PATIENT(S): Twenty-nine nondiabetic men aged 18-66 years were enrolled. Of these, 28 completed the study: 17 had ED, and 11 did not. INTERVENTION(S): Validated ED questionnaires, examination, serum hormones evaluation, and oral glucose tolerance testing. MAIN OUTCOME MEASURE(S): Association of IR with ED. RESULT(S): The association between worsening degrees of both lower urinary tract symptoms (LUTS) and ED was reaffirmed, as was a potential correlation between the two-epinephrine. There was a negative association between serum levels of epinephrine and scores on the 5-item version of the International Index of Erectile Dysfunction for ED (Spearman correlation coefficient = -0.38). On the other hand, men with ED were not more likely to have IR compared with controls. CONCLUSION(S): Epinephrine may be the common link between ED and LUTS. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: J Jordan; J Tank; M Stoffels; G Franke; N J Christensen; F C Luft; M Boschmann Journal: J Clin Endocrinol Metab Date: 2001-06 Impact factor: 5.958
Authors: A Martin-Morales; J J Sanchez-Cruz; I Saenz de Tejada; L Rodriguez-Vela; J F Jimenez-Cruz; R Burgos-Rodriguez Journal: J Urol Date: 2001-08 Impact factor: 7.450