| Literature DB >> 19061838 |
Stefano Cairo1, Carolina Armengol, Aurélien De Reyniès, Yu Wei, Emilie Thomas, Claire-Angélique Renard, Andrei Goga, Asha Balakrishnan, Michaela Semeraro, Lionel Gresh, Marco Pontoglio, Hélène Strick-Marchand, Florence Levillayer, Yann Nouet, David Rickman, Frédéric Gauthier, Sophie Branchereau, Laurence Brugières, Véronique Laithier, Raymonde Bouvier, Françoise Boman, Giuseppe Basso, Jean-François Michiels, Paul Hofman, Francine Arbez-Gindre, Hélène Jouan, Marie-Christine Rousselet-Chapeau, Dominique Berrebi, Luc Marcellin, François Plenat, Dominique Zachar, Madeleine Joubert, Janick Selves, Dominique Pasquier, Paulette Bioulac-Sage, Michael Grotzer, Margaret Childs, Monique Fabre, Marie-Annick Buendia.
Abstract
Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy.Entities:
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Year: 2008 PMID： 19061838 DOI： 10.1016/j.ccr.2008.11.002
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743