Literature DB >> 19061834

The aneuploidy paradox in cell growth and tumorigenesis.

Beth A Weaver1, Don W Cleveland.   

Abstract

Aneuploidy, an abnormal chromosome number, is a frequent characteristic of malignant cells, leading to the suggestion that aneuploidy drives tumorigenesis. In a recent issue of Science, Williams et al. identified a paradoxical relationship between aneuploidy and its linkage to tumorigenesis: chromosome gains in nontransformed cells are antiproliferative, despite frequently occurring in human tumors.

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Year:  2008        PMID： 19061834      PMCID： PMC3132552          DOI： 10.1016/j.ccr.2008.11.011

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  Does aneuploidy cause cancer?

Authors:  Beth A A Weaver; Don W Cleveland
Journal:  Curr Opin Cell Biol       Date:  2006-10-12       Impact factor: 8.382

2.  Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.

Authors:  Chinthalapally V Rao; Yang-Ming Yang; Malisetty V Swamy; Tongyi Liu; Yuqiang Fang; Radma Mahmood; Meena Jhanwar-Uniyal; Wei Dai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-14       Impact factor: 11.205

3.  Aneuploidy acts both oncogenically and as a tumor suppressor.

Authors:  Beth A A Weaver; Alain D Silk; Cristina Montagna; Pascal Verdier-Pinard; Don W Cleveland
Journal:  Cancer Cell       Date:  2006-12-28       Impact factor: 31.743

4.  Alteration of gene expression by chromosome loss in the postnatal mouse brain.

Authors:  Dhruv Kaushal; James J A Contos; Kai Treuner; Amy H Yang; Marcy A Kingsbury; Stevens K Rehen; Michael J McConnell; Masaru Okabe; Carrolee Barlow; Jerold Chun
Journal:  J Neurosci       Date:  2003-07-02       Impact factor: 6.167

5.  A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

Authors:  S X Shen; Z Weaver; X Xu; C Li; M Weinstein; L Chen; X Y Guan; T Ried; C X Deng
Journal:  Oncogene       Date:  1998-12-17       Impact factor: 9.867

6.  MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.

Authors:  Zdenka Matijasevic; Heather A Steinman; Kathleen Hoover; Stephen N Jones
Journal:  Mol Cell Biol       Date:  2007-11-26       Impact factor: 4.272

7.  Effects of aneuploidy on cellular physiology and cell division in haploid yeast.

Authors:  Eduardo M Torres; Tanya Sokolsky; Cheryl M Tucker; Leon Y Chan; Monica Boselli; Maitreya J Dunham; Angelika Amon
Journal:  Science       Date:  2007-08-17       Impact factor: 47.728

Review 8.  The spindle-assembly checkpoint in space and time.

Authors:  Andrea Musacchio; Edward D Salmon
Journal:  Nat Rev Mol Cell Biol       Date:  2007-04-11       Impact factor: 94.444

9.  Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

Authors:  Bret R Williams; Vineet R Prabhu; Karen E Hunter; Christina M Glazier; Charles A Whittaker; David E Housman; Angelika Amon
Journal:  Science       Date:  2008-10-31       Impact factor: 47.728
  9 in total
  48 in total

1.  Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC).

Authors:  Aaron R Tipton; Michael Tipton; Tim Yen; Song-Tao Liu
Journal:  Cell Cycle       Date:  2011-11-01       Impact factor: 4.534

Review 2.  Autosomal dominant polycystic kidney disease: the last 3 years.

Authors:  Vicente E Torres; Peter C Harris
Journal:  Kidney Int       Date:  2009-05-20       Impact factor: 10.612

Review 3.  Mitosis as an anti-cancer drug target.

Authors:  Anna-Leena Salmela; Marko J Kallio
Journal:  Chromosoma       Date:  2013-06-18       Impact factor: 4.316

4.  High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.

Authors:  Jewel Daniel; Jonathan Coulter; Ju-Hyung Woo; Kathleen Wilsbach; Edward Gabrielson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-14       Impact factor: 11.205

5.  Interrogating cell division errors using random and chromosome-specific missegregation approaches.

Authors:  Peter Ly; Don W Cleveland
Journal:  Cell Cycle       Date:  2017-06-26       Impact factor: 4.534

6.  Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.

Authors:  Hiroshi Y Yamada; Yixin Yao; Xiaoxing Wang; Yuting Zhang; Ying Huang; Wei Dai; Chinthalapally V Rao
Journal:  Cell Cycle       Date:  2012-02-01       Impact factor: 4.534

Review 7.  Causes and consequences of aneuploidy in cancer.

Authors:  David J Gordon; Benjamin Resio; David Pellman
Journal:  Nat Rev Genet       Date:  2012-01-24       Impact factor: 53.242

8.  Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.

Authors:  Kexi Wang; Brianne Sturt-Gillespie; James C Hittle; Dawn Macdonald; Gordon K Chan; Tim J Yen; Song-Tao Liu
Journal:  J Biol Chem       Date:  2014-07-10       Impact factor: 5.157

9.  Methylation and expression analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor regions on 12p.

Authors:  Josef Davidsson; Bertil Johansson
Journal:  Epigenetics       Date:  2016-02-18       Impact factor: 4.528

10.  BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).

Authors:  Y Niikura; H Ogi; K Kikuchi; K Kitagawa
Journal:  Cell Death Differ       Date:  2010-01-08       Impact factor: 15.828
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