PURPOSE: The aim of this study was to investigate the role of dynamic subtraction magnetic resonance imaging (MRI) in detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. MATERIALS AND METHODS: MR images of 32 patients with cirrhosis were retrospectively investigated. The standard sequence images of the patients were evaluated for detection of HCC, and then the subtracted images of dynamic contrast-enhanced series were evaluated. The sensitivity, specificity, and accuracy of standard technique and additional use of subtracted images were investigated. RESULTS: In detection of at least one HCC, standard protocol was useful in 14 of 17 (82.3%) patients; by additional use of subtraction imaging all 17 (100%) patients with HCC were detected. For detection of the correct number of HCC tumors, standard protocol was found to have 61.5% sensitivity, 78.9% specificity, and 71.8% accuracy. The use of subtracted images increased the sensitivity to 85.7%, specificity to 83.3%, and accuracy to 84.3%. CONCLUSION: Subtraction is a simple automatic procedure that is commonly available in most MRI systems. The use of subtraction of dynamic contrast-enhanced series facilitates the detection of HCC in disorganized architecture of cirrhotic livers.
PURPOSE: The aim of this study was to investigate the role of dynamic subtraction magnetic resonance imaging (MRI) in detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. MATERIALS AND METHODS: MR images of 32 patients with cirrhosis were retrospectively investigated. The standard sequence images of the patients were evaluated for detection of HCC, and then the subtracted images of dynamic contrast-enhanced series were evaluated. The sensitivity, specificity, and accuracy of standard technique and additional use of subtracted images were investigated. RESULTS: In detection of at least one HCC, standard protocol was useful in 14 of 17 (82.3%) patients; by additional use of subtraction imaging all 17 (100%) patients with HCC were detected. For detection of the correct number of HCC tumors, standard protocol was found to have 61.5% sensitivity, 78.9% specificity, and 71.8% accuracy. The use of subtracted images increased the sensitivity to 85.7%, specificity to 83.3%, and accuracy to 84.3%. CONCLUSION: Subtraction is a simple automatic procedure that is commonly available in most MRI systems. The use of subtraction of dynamic contrast-enhanced series facilitates the detection of HCC in disorganized architecture of cirrhotic livers.
Authors: Jimi Huh; So Yeon Kim; Benjamin M Yeh; Seung Soo Lee; Kyoung Won Kim; En-Haw Wu; Z Jane Wang; Li-qin Zhao; Wei Chou Chang Journal: Korean J Radiol Date: 2015-10-26 Impact factor: 3.500