B C Gladen1, W J Rogan. 1. Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Abstract
OBJECTIVE: Determining whether early developmental effects of perinatal exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE) persist. DESIGN: Cohort followed from birth; ages now 5 1/2 to 10 1/2 years. SETTING: General community. PARTICIPANTS: Volunteer sample of 859 children, of whom 712 had been examined with the McCarthy Scales of Children's Abilities at 3, 4, or 5 years; 506 sent report cards. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Neither transplacental nor breast-feeding exposure to PCBs or DDE affected McCarthy scores at 3, 4, or 5 years. There was no statistically significant relationship between poorer grades and PCB or DDE exposure by either route. CONCLUSIONS: The deficits seen in these children on the Bayley Scales of Infant Development through 2 years of age are no longer apparent.
OBJECTIVE: Determining whether early developmental effects of perinatal exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE) persist. DESIGN: Cohort followed from birth; ages now 5 1/2 to 10 1/2 years. SETTING: General community. PARTICIPANTS: Volunteer sample of 859 children, of whom 712 had been examined with the McCarthy Scales of Children's Abilities at 3, 4, or 5 years; 506 sent report cards. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Neither transplacental nor breast-feeding exposure to PCBs or DDE affected McCarthy scores at 3, 4, or 5 years. There was no statistically significant relationship between poorer grades and PCB or DDE exposure by either route. CONCLUSIONS: The deficits seen in these children on the Bayley Scales of Infant Development through 2 years of age are no longer apparent.
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