PURPOSE: To compare the long-term outcomes of macular translocation (MT) and autologous RPE-choroid patch graft (PG) in patients with neovascular age-related macular degeneration (AMD). METHODS: This is a retrospective review of the first 12 patients who underwent MT and the first 12 patients who underwent PG. Visual acuity (VA), contrast sensitivity (CS), clinical findings, and complications were recorded. Microperimetry and fundus imaging were reviewed. Outcome measures were the change in VA and CS over 3 years in each group and rates of complication. Microperimetry and fixation in three best cases from each group were described. RESULTS: The two groups were matched for age and VA. Median follow-up durations were 41 (MT) and 38 (PG) months. Median VA (logMAR) was maintained in the MT group: 0.90 at baseline and 0.69 at 3 years (P=0.09) whereas in the PG group, median VA declined from 0.87 to 1.38 at 3 years (P<0.001). Both surgical modalities had high rates of detachment and macular edema. Although more extensive RPE damage occurred in PG, the graft resisted growth of recurrent choroidal neovascularization toward the fovea. Near normal VA was achievable by each technique but macular sensitivity and fixation stability were superior in the MT group. CONCLUSIONS: In the present cohort, MT maintained VA for 3 years but PG did not. This outcome may be related to the differences in surgical approach, source of RPE, and choroidal perfusion. The authors recommend MT in preference to PG for treatment of patients with the second eye affected by neovascular AMD unsuitable for other treatment.
PURPOSE: To compare the long-term outcomes of macular translocation (MT) and autologous RPE-choroid patch graft (PG) in patients with neovascular age-related macular degeneration (AMD). METHODS: This is a retrospective review of the first 12 patients who underwent MT and the first 12 patients who underwent PG. Visual acuity (VA), contrast sensitivity (CS), clinical findings, and complications were recorded. Microperimetry and fundus imaging were reviewed. Outcome measures were the change in VA and CS over 3 years in each group and rates of complication. Microperimetry and fixation in three best cases from each group were described. RESULTS: The two groups were matched for age and VA. Median follow-up durations were 41 (MT) and 38 (PG) months. Median VA (logMAR) was maintained in the MT group: 0.90 at baseline and 0.69 at 3 years (P=0.09) whereas in the PG group, median VA declined from 0.87 to 1.38 at 3 years (P<0.001). Both surgical modalities had high rates of detachment and macular edema. Although more extensive RPE damage occurred in PG, the graft resisted growth of recurrent choroidal neovascularization toward the fovea. Near normal VA was achievable by each technique but macular sensitivity and fixation stability were superior in the MT group. CONCLUSIONS: In the present cohort, MT maintained VA for 3 years but PG did not. This outcome may be related to the differences in surgical approach, source of RPE, and choroidal perfusion. The authors recommend MT in preference to PG for treatment of patients with the second eye affected by neovascular AMD unsuitable for other treatment.
Authors: Paul Whiting; Julie Kerby; Peter Coffey; Lyndon da Cruz; Ruth McKernan Journal: Philos Trans R Soc Lond B Biol Sci Date: 2015-10-19 Impact factor: 6.237
Authors: David E Buchholz; Britney O Pennington; Roxanne H Croze; Cassidy R Hinman; Peter J Coffey; Dennis O Clegg Journal: Stem Cells Transl Med Date: 2013-04-18 Impact factor: 6.940
Authors: Lyndon da Cruz; Kate Fynes; Odysseas Georgiadis; Julie Kerby; Yvonne H Luo; Ahmad Ahmado; Amanda Vernon; Julie T Daniels; Britta Nommiste; Shazeen M Hasan; Sakina B Gooljar; Amanda-Jayne F Carr; Anthony Vugler; Conor M Ramsden; Magda Bictash; Mike Fenster; Juliette Steer; Tricia Harbinson; Anna Wilbrey; Adnan Tufail; Gang Feng; Mark Whitlock; Anthony G Robson; Graham E Holder; Mandeep S Sagoo; Peter T Loudon; Paul Whiting; Peter J Coffey Journal: Nat Biotechnol Date: 2018-03-19 Impact factor: 54.908
Authors: Amanda-Jayne Carr; Anthony A Vugler; Sherry T Hikita; Jean M Lawrence; Carlos Gias; Li Li Chen; David E Buchholz; Ahmad Ahmado; Ma'ayan Semo; Matthew J K Smart; Shazeen Hasan; Lyndon da Cruz; Lincoln V Johnson; Dennis O Clegg; Pete J Coffey Journal: PLoS One Date: 2009-12-03 Impact factor: 3.240
Authors: Marcin Stopa; Jarosław Kocięcki; Piotr Rakowicz; Andrzej Dmitriew Journal: Wideochir Inne Tech Maloinwazyjne Date: 2012-06-22 Impact factor: 1.195