Literature DB >> 19060152

Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination.

Joseph A Sorg1, Abraham L Sonenshein.   

Abstract

Some cholate derivatives that are normal components of bile can act with glycine to induce the germination of Clostridium difficile spores, but at least one bile component, chenodeoxycholate, does not induce germination. Here we show that chenodeoxycholate inhibits the germination of C. difficile spores in response to cholate and taurocholate.

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Year:  2008        PMID： 19060152      PMCID： PMC2632082          DOI： 10.1128/JB.01260-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  18 in total

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Journal:  Curr Opin Microbiol       Date:  2003-12       Impact factor: 7.934

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Journal:  Gut       Date:  2001-12       Impact factor: 23.059

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Authors:  H S Mekhjian; S F Phillips; A F Hofmann
Journal:  Dig Dis Sci       Date:  1979-07       Impact factor: 3.199

5.  Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine.

Authors:  T C Northfield; I McColl
Journal:  Gut       Date:  1973-07       Impact factor: 23.059

6.  Efficiency of various bile salt preparations for stimulation of Clostridium difficile spore germination.

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Journal:  J Clin Microbiol       Date:  1983-10       Impact factor: 5.948

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Authors:  R Wax; E Freese; M Cashel
Journal:  J Bacteriol       Date:  1967-09       Impact factor: 3.490

Review 8.  Treatment of Clostridium difficile infection.

Authors:  Dale N Gerding; Carlene A Muto; Robert C Owens
Journal:  Clin Infect Dis       Date:  2008-01-15       Impact factor: 9.079

9.  Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile.

Authors:  K H Wilson; M J Kennedy; F R Fekety
Journal:  J Clin Microbiol       Date:  1982-03       Impact factor: 5.948

10.  Bile salts and glycine as cogerminants for Clostridium difficile spores.

Authors:  Joseph A Sorg; Abraham L Sonenshein
Journal:  J Bacteriol       Date:  2008-02-01       Impact factor: 3.490
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  95 in total

1.  Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.

Authors:  Alexa R Weingarden; Chi Chen; Ningning Zhang; Carolyn T Graiziger; Peter I Dosa; Clifford J Steer; Megan K Shaughnessy; James R Johnson; Michael J Sadowsky; Alexander Khoruts
Journal:  J Clin Gastroenterol       Date:  2016-09       Impact factor: 3.062

Review 2.  Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection.

Authors:  Alyse L Frisbee; William A Petri
Journal:  Trends Mol Med       Date:  2020-02-17       Impact factor: 11.951

Review 3.  Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance.

Authors:  Robert A Britton; Vincent B Young
Journal:  Trends Microbiol       Date:  2012-05-15       Impact factor: 17.079

4.  Mapping interactions between germinants and Clostridium difficile spores.

Authors:  Amber Howerton; Norma Ramirez; Ernesto Abel-Santos
Journal:  J Bacteriol       Date:  2010-10-22       Impact factor: 3.490

Review 5.  Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract.

Authors:  Jenessa A Winston; Casey M Theriot
Journal:  Anaerobe       Date:  2016-05-07       Impact factor: 3.331

Review 6.  Clostridium difficile spore biology: sporulation, germination, and spore structural proteins.

Authors:  Daniel Paredes-Sabja; Aimee Shen; Joseph A Sorg
Journal:  Trends Microbiol       Date:  2014-05-07       Impact factor: 17.079

7.  Spore Cortex Hydrolysis Precedes Dipicolinic Acid Release during Clostridium difficile Spore Germination.

Authors:  Michael B Francis; Charlotte A Allen; Joseph A Sorg
Journal:  J Bacteriol       Date:  2015-04-27       Impact factor: 3.490

Review 8.  Clostridium difficile colitis: pathogenesis and host defence.

Authors:  Michael C Abt; Peter T McKenney; Eric G Pamer
Journal:  Nat Rev Microbiol       Date:  2016-08-30       Impact factor: 60.633

9.  Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea.

Authors:  Eric J Battaglioli; Vanessa L Hale; Jun Chen; Patricio Jeraldo; Coral Ruiz-Mojica; Bradley A Schmidt; Vayu M Rekdal; Lisa M Till; Lutfi Huq; Samuel A Smits; William J Moor; Yava Jones-Hall; Thomas Smyrk; Sahil Khanna; Darrell S Pardi; Madhusudan Grover; Robin Patel; Nicholas Chia; Heidi Nelson; Justin L Sonnenburg; Gianrico Farrugia; Purna C Kashyap
Journal:  Sci Transl Med       Date:  2018-10-24       Impact factor: 17.956

10.  Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Authors:  Mohamad El-Zaatari; Yu-Ming Chang; Min Zhang; Matthew Franz; Andrew Shreiner; Andrew J McDermott; Koenraad F van der Sluijs; René Lutter; Helmut Grasberger; Nobuhiko Kamada; Vincent B Young; Gary B Huffnagle; John Y Kao
Journal:  J Immunol       Date:  2014-06-16       Impact factor: 5.422
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