BACKGROUND: Left ventricular assist device support in heart failure patients leads to changes in mRNA and protein expression in the myocardium. METHODS: MicroRNA's are important regulators of various cellular processes, so changes in their expression were tested by Q-PCR methods. RESULTS: LVAD support (independently of the duration) leads to a decrease of the expression of miR-1, miR-133a and miR-133b in DCM patients but to an increase in expression in IHD patients. The expression of miR's pre- and post-LVAD in heart failure patients was low compared to the level of miR's in control myocardial tissue. CONCLUSIONS: Alterations in miRs expression might also be important during repair processes in IHD patients.
BACKGROUND: Left ventricular assist device support in heart failurepatients leads to changes in mRNA and protein expression in the myocardium. METHODS: MicroRNA's are important regulators of various cellular processes, so changes in their expression were tested by Q-PCR methods. RESULTS: LVAD support (independently of the duration) leads to a decrease of the expression of miR-1, miR-133a and miR-133b in DCMpatients but to an increase in expression in IHD patients. The expression of miR's pre- and post-LVAD in heart failurepatients was low compared to the level of miR's in control myocardial tissue. CONCLUSIONS: Alterations in miRs expression might also be important during repair processes in IHD patients.
Authors: Richard Myers; Valeriy Timofeyev; Ning Li; Catherine Kim; Hannah A Ledford; Padmini Sirish; Victor Lau; Yinuo Zhang; Kiran Fayyaz; Anil Singapuri; Javier E Lopez; Anne A Knowlton; Xiao-Dong Zhang; Nipavan Chiamvimonvat Journal: Circ Arrhythm Electrophysiol Date: 2015-05-20
Authors: Carmen C Sucharov; David P Kao; J David Port; Anis Karimpour-Fard; Robert A Quaife; Wayne Minobe; Karin Nunley; Brian D Lowes; Edward M Gilbert; Michael R Bristow Journal: JCI Insight Date: 2017-01-26
Authors: Scot J Matkovich; Wei Wang; Yizheng Tu; William H Eschenbacher; Lisa E Dorn; Gianluigi Condorelli; Abhinav Diwan; Jeanne M Nerbonne; Gerald W Dorn Journal: Circ Res Date: 2009-11-05 Impact factor: 17.367